KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 7,335 Value ($000) $1,008 Avg Close $146.88 Range $122.80 - $182.16

Q1 2022

Shares 25,310 Value ($000) $1,684 Avg Close $62.42 Range $50.03 - $73.94

Q4 2020

Shares 101,044 Value ($000) $6,063 Avg Close $49.94 Range $40.04 - $62.95

Q3 2020

Shares 184,573 Value ($000) $7,946 Avg Close $43.43 Range $37.68 - $48.80

Q2 2020

Shares 144,573 Value ($000) $5,988 Avg Close $48.11 Range $35.33 - $61.86

Q4 2019

Shares 86,280 Value ($000) $4,778 Avg Close $49.06 Range $31.89 - $66.50

Q3 2019

Shares 117,625 Value ($000) $4,085 Avg Close $44.70 Range $33.62 - $51.67

Q2 2019

Shares 117,625 Value ($000) $4,737 Avg Close $32.69 Range $22.02 - $46.90

Q1 2019

Shares 181,625 Value ($000) $5,975 Avg Close $23.57 Range $18.50 - $33.12

Q4 2018

Shares 174,625 Value ($000) $3,629 Avg Close $20.94 Range $14.30 - $28.75

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	7,335	$1,008	$146.88	$122.80 - $182.16
Q1 2022	25,310	$1,684	$62.42	$50.03 - $73.94
Q4 2020	101,044	$6,063	$49.94	$40.04 - $62.95
Q3 2020	184,573	$7,946	$43.43	$37.68 - $48.80
Q2 2020	144,573	$5,988	$48.11	$35.33 - $61.86
Q4 2019	86,280	$4,778	$49.06	$31.89 - $66.50
Q3 2019	117,625	$4,085	$44.70	$33.62 - $51.67
Q2 2019	117,625	$4,737	$32.69	$22.02 - $46.90
Q1 2019	181,625	$5,975	$23.57	$18.50 - $33.12
Q4 2018	174,625	$3,629	$20.94	$14.30 - $28.75