| JANUS HENDERSON GROUP PLC | 5,509,635 | $54,669 |
| RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | $49,650 |
| BlackRock, Inc. | 4,907,563 | $48,732 |
| Paradigm Biocapital Advisors LP | 4,763,198 | $47,299 |
| Vestal Point Capital, LP | 4,475,000 | $44,437 |
| Frazier Life Sciences Management, L.P. | 4,424,725 | $43,938 |
| VANGUARD GROUP INC | 3,894,310 | $38,670 |
| CITADEL ADVISORS LLC | 3,774,317 | $37,479 |
| Avoro Capital Advisors LLC | 3,300,000 | $32,769 |
| Affinity Asset Advisors, LLC | 3,200,000 | $31,776 |
| Woodline Partners LP | 3,197,760 | $31,754 |
| STATE STREET CORP | 3,187,722 | $31,654 |
| ORBIMED ADVISORS LLC | 2,125,000 | $21,101 |
| Point72 Asset Management, L.P. | 1,894,722 | $18,815 |
| Octagon Capital Advisors LP | 1,725,000 | $17,129 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,635,026 | $16,236 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,445,887 | $14,361 |
| ADAR1 Capital Management, LLC | 1,393,161 | $13,834 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,250,000 | $12,413 |
| 683 Capital Management, LLC | 1,120,000 | $11,122 |
| Nantahala Capital Management, LLC | 1,000,000 | $9,930 |
| MILLENNIUM MANAGEMENT LLC | 908,024 | $9,017 |
| Blackstone Inc. | 904,959 | $8,986 |
| DIMENSIONAL FUND ADVISORS LP | 862,892 | $8,568 |
| GOLDMAN SACHS GROUP INC | 781,855 | $7,764 |
| Siren, L.L.C. | 720,622 | $7,156 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 617,608 | $6,133 |
| Ikarian Capital, LLC | 513,011 | $5,094 |
| D. E. Shaw & Co., Inc. | 480,205 | $4,768 |
| Invesco Ltd. | 463,029 | $4,598 |
| NORTHERN TRUST CORP | 457,052 | $4,539 |
| Verition Fund Management LLC | 428,458 | $4,255 |
| TWO SIGMA INVESTMENTS, LP | 400,567 | $3,978 |
| DAFNA Capital Management LLC | 340,859 | $3,385 |
| AQR CAPITAL MANAGEMENT LLC | 337,386 | $3,350 |
| UBS Group AG | 281,083 | $2,791 |
| BNP PARIBAS ARBITRAGE, SA | 257,417 | $2,556 |
| AMERIPRISE FINANCIAL INC | 243,294 | $2,416 |
| Y-Intercept (Hong Kong) Ltd | 231,163 | $2,295 |
| RENAISSANCE TECHNOLOGIES LLC | 217,772 | $2,162 |
| Nuveen, LLC | 211,529 | $2,100 |
| Privium Fund Management B.V. | 192,550 | $1,912 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 192,210 | $1,909 |
| BARCLAYS PLC | 188,754 | $1,874 |
| Spruce Street Capital LP | 175,000 | $1,738 |
| Bank of New York Mellon Corp | 166,749 | $1,656 |
| BANK OF AMERICA CORP /DE/ | 160,288 | $1,592 |
| MORGAN STANLEY | 140,181 | $1,392 |
| JANE STREET GROUP, LLC | 140,096 | $1,391 |
| PERCEPTIVE ADVISORS LLC | 139,835 | $1,389 |
| BOOTHBAY FUND MANAGEMENT, LLC | 136,377 | $1,354 |
| Qube Research & Technologies Ltd | 133,257 | $1,323 |
| Burkehill Global Management, LP | 125,000 | $1,241 |
| Rafferty Asset Management, LLC | 102,159 | $1,014 |
| Squarepoint Ops LLC | 92,608 | $920 |
| WELLINGTON MANAGEMENT GROUP LLP | 83,230 | $826 |
| TWO SIGMA ADVISERS, LP | 81,300 | $807 |
| WELLS FARGO & COMPANY/MN | 70,736 | $702 |
| RHUMBLINE ADVISERS | 69,369 | $689 |
| Atom Investors LP | 68,491 | $680 |
| ALLIANCEBERNSTEIN L.P. | 61,810 | $614 |
| DEUTSCHE BANK AG\ | 57,166 | $568 |
| ACADIAN ASSET MANAGEMENT LLC | 50,909 | $1 |
| AMERICAN CENTURY COMPANIES INC | 45,988 | $457 |
| PROFUND ADVISORS LLC | 38,054 | $378 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,009 | $367 |
| MetLife Investment Management, LLC | 35,721 | $355 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,257 | $349 |
| PANAGORA ASSET MANAGEMENT INC | 34,297 | $341 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,872 | $0 |
| Graham Capital Management, L.P. | 32,898 | $327 |
| JPMORGAN CHASE & CO | 29,861 | $297 |
| Virtus Investment Advisers, LLC | 27,230 | $270 |
| WINTON GROUP Ltd | 26,900 | $267 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 26,209 | $252 |
| Susquehanna Portfolio Strategies, LLC | 26,205 | $260 |
| IEQ CAPITAL, LLC | 24,692 | $245 |
| Cerity Partners LLC | 22,439 | $223 |
| Pale Fire Capital SE | 22,302 | $221 |
| OMERS ADMINISTRATION Corp | 20,900 | $208 |
| Soltis Investment Advisors LLC | 20,000 | $199 |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,887 | $197 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,147 | $190 |
| CWM, LLC | 18,953 | $0 |
| SG Americas Securities, LLC | 18,640 | $0 |
| Vanguard Personalized Indexing Management, LLC | 16,436 | $163 |
| Police & Firemen's Retirement System of New Jersey | 16,373 | $163 |
| Persistent Asset Partners Ltd | 16,025 | $159 |
| CITIGROUP INC | 15,293 | $152 |
| ProShare Advisors LLC | 14,752 | $146 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 14,330 | $136 |
| INTECH INVESTMENT MANAGEMENT LLC | 14,188 | $141 |
| CAXTON CORP | 13,943 | $138 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13,400 | $133 |
| FMR LLC | 13,388 | $133 |
| SIMPLEX TRADING, LLC | 13,031 | $129 |
| RAYMOND JAMES FINANCIAL INC | 12,538 | $125 |
| China Universal Asset Management Co., Ltd. | 11,893 | $118 |
| AlphaQuest LLC | 11,726 | $116 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,555 | $109 |
| 44 other institutions | 125,415 | $1,086 |