LEXEO THERAPEUTICS INC

Institution	Shares	Value ($000)
Octagon Capital Advisors LP	1,725,000	$17,129
Paradigm Biocapital Advisors LP	4,763,198	$47,299
RA CAPITAL MANAGEMENT, L.P.	5,000,000	$49,650
ORBIMED ADVISORS LLC	2,125,000	$21,101
Avoro Capital Advisors LLC	3,300,000	$32,769
Nantahala Capital Management, LLC	1,000,000	$9,930
SUVRETTA CAPITAL MANAGEMENT, LLC	1,250,000	$12,413
Burkehill Global Management, LP	125,000	$1,241
Persistent Asset Partners Ltd	16,025	$159
Virtus Investment Advisers, LLC	27,230	$270
Y-Intercept (Hong Kong) Ltd	231,163	$2,295
Atom Investors LP	68,491	$680
PROFUND ADVISORS LLC	38,054	$378
WINTON GROUP Ltd	26,900	$267
Caitong International Asset Management Co., Ltd	3,714	$37
Graham Capital Management, L.P.	32,898	$327
Rafferty Asset Management, LLC	102,159	$1,014
Invesco Ltd.	463,029	$4,598
AlphaQuest LLC	11,726	$116
Qube Research & Technologies Ltd	133,257	$1,323

Increased Positions (57)

Vestal Point Capital, LP

Value ($000) $44,437 (+105.9%) Shares 4,475,000 (+37.7%)

683 Capital Management, LLC

Value ($000) $11,122 (+81.5%) Shares 1,120,000 (+21.4%)

Siren, L.L.C.

Value ($000) $7,156 (+78.6%) Shares 720,622 (+19.4%)

Woodline Partners LP

Value ($000) $31,754 (+85.9%) Shares 3,197,760 (+24.3%)

STATE STREET CORP

Value ($000) $31,654 (+775.0%) Shares 3,187,722 (+485.1%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $3,978 (+606.7%) Shares 400,567 (+372.6%)

BlackRock, Inc.

Value ($000) $48,732 (+238.0%) Shares 4,907,563 (+126.0%)

D. E. Shaw & Co., Inc.

Value ($000) $4,768 (+5502.5%) Shares 480,205 (+3646.3%)

VANGUARD GROUP INC

Value ($000) $38,670 (+161.6%) Shares 3,894,310 (+74.9%)

GOLDMAN SACHS GROUP INC

Value ($000) $7,764 (+721.1%) Shares 781,855 (+449.0%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $14,361 (+199.5%) Shares 1,445,887 (+100.3%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $2,556 (+1152.8%) Shares 257,417 (+737.8%)

NORTHERN TRUST CORP

Value ($000) $4,539 (+189.1%) Shares 457,052 (+93.3%)

Nuveen, LLC

Value ($000) $2,100 (+855.6%) Shares 211,529 (+539.0%)

BARCLAYS PLC

Value ($000) $1,874 (+312.9%) Shares 188,754 (+275.9%)

BANK OF AMERICA CORP /DE/

Value ($000) $1,592 (+747.7%) Shares 160,288 (+466.8%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $2,162 (+118.1%) Shares 217,772 (+45.9%)

Bank of New York Mellon Corp

Value ($000) $1,656 (+247.9%) Shares 166,749 (+132.6%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $1,909 (+171.8%) Shares 192,210 (+81.7%)

AMERIPRISE FINANCIAL INC

Value ($000) $2,416 (+118.5%) Shares 243,294 (+46.1%)

Institution	Prev Shares	Curr Shares	Change
Vestal Point Capital, LP	3,250,000	4,475,000	+1,225,000 (+37.7%)
683 Capital Management, LLC	922,662	1,120,000	+197,338 (+21.4%)
Siren, L.L.C.	603,435	720,622	+117,187 (+19.4%)
Woodline Partners LP	2,572,162	3,197,760	+625,598 (+24.3%)
STATE STREET CORP	544,845	3,187,722	+2,642,877 (+485.1%)
TWO SIGMA INVESTMENTS, LP	84,763	400,567	+315,804 (+372.6%)
BlackRock, Inc.	2,171,092	4,907,563	+2,736,471 (+126.0%)
D. E. Shaw & Co., Inc.	12,818	480,205	+467,387 (+3646.3%)
VANGUARD GROUP INC	2,226,290	3,894,310	+1,668,020 (+74.9%)
GOLDMAN SACHS GROUP INC	142,402	781,855	+639,453 (+449.0%)
GEODE CAPITAL MANAGEMENT, LLC	721,881	1,445,887	+724,006 (+100.3%)
BNP PARIBAS ARBITRAGE, SA	30,727	257,417	+226,690 (+737.8%)
NORTHERN TRUST CORP	236,453	457,052	+220,599 (+93.3%)
Nuveen, LLC	33,102	211,529	+178,427 (+539.0%)
BARCLAYS PLC	50,210	188,754	+138,544 (+275.9%)
BANK OF AMERICA CORP /DE/	28,279	160,288	+132,009 (+466.8%)
RENAISSANCE TECHNOLOGIES LLC	149,300	217,772	+68,472 (+45.9%)
Bank of New York Mellon Corp	71,677	166,749	+95,072 (+132.6%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	105,760	192,210	+86,450 (+81.7%)
AMERIPRISE FINANCIAL INC	166,538	243,294	+76,756 (+46.1%)

Decreased Positions (24)

CAXTON CORP

Value ($000) $138 (+20.3%) Shares 13,943 (-19.6%)

Affinity Asset Advisors, LLC

Value ($000) $31,776 (+23.6%) Shares 3,200,000 (-17.3%)

SILVERARC CAPITAL MANAGEMENT, LLC

Value ($000) $6,133 (+18.6%) Shares 617,608 (-20.7%)

ADAR1 Capital Management, LLC

Value ($000) $13,834 (+36.0%) Shares 1,393,161 (-9.1%)

DAFNA Capital Management LLC

Value ($000) $3,385 (+42.4%) Shares 340,859 (-4.8%)

Ikarian Capital, LLC

Value ($000) $5,094 (+35.2%) Shares 513,011 (-9.6%)

BALYASNY ASSET MANAGEMENT L.P.

Value ($000) $16,236 (-37.5%) Shares 1,635,026 (-58.2%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $9,017 (-41.3%) Shares 908,024 (-60.8%)

Blackstone Inc.

Value ($000) $8,986 (+20.3%) Shares 904,959 (-19.6%)

JANUS HENDERSON GROUP PLC

Value ($000) $54,669 (+35.0%) Shares 5,509,635 (-9.8%)

BOOTHBAY FUND MANAGEMENT, LLC

Value ($000) $1,354 (+12.8%) Shares 136,377 (-24.5%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $133 (-58.6%) Shares 13,400 (-72.3%)

Pale Fire Capital SE

Value ($000) $221 (-0.9%) Shares 22,302 (-33.7%)

XTX Topco Ltd

Value ($000) $111 (-37.6%) Shares 11,144 (-58.3%)

Point72 Asset Management, L.P.

Value ($000) $18,815 (+45.9%) Shares 1,894,722 (-2.4%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $8,568 (+41.4%) Shares 862,892 (-5.4%)

AQR CAPITAL MANAGEMENT LLC

Value ($000) $3,350 (+45.0%) Shares 337,386 (-3.0%)

IEQ CAPITAL, LLC

Value ($000) $245 (+10.0%) Shares 24,692 (-26.5%)

Tower Research Capital LLC (TRC)

Value ($000) $8 (-66.9%) Shares 826 (-77.9%)

Cerity Partners LLC

Value ($000) $223 (+42.3%) Shares 22,439 (-4.9%)

Institution	Prev Shares	Curr Shares	Change
CAXTON CORP	17,332	13,943	-3,389 (-19.6%)
Affinity Asset Advisors, LLC	3,870,527	3,200,000	-670,527 (-17.3%)
SILVERARC CAPITAL MANAGEMENT, LLC	778,611	617,608	-161,003 (-20.7%)
ADAR1 Capital Management, LLC	1,531,953	1,393,161	-138,792 (-9.1%)
DAFNA Capital Management LLC	358,083	340,859	-17,224 (-4.8%)
Ikarian Capital, LLC	567,601	513,011	-54,590 (-9.6%)
BALYASNY ASSET MANAGEMENT L.P.	3,913,788	1,635,026	-2,278,762 (-58.2%)
MILLENNIUM MANAGEMENT LLC	2,313,642	908,024	-1,405,618 (-60.8%)
Blackstone Inc.	1,124,922	904,959	-219,963 (-19.6%)
JANUS HENDERSON GROUP PLC	6,105,527	5,509,635	-595,892 (-9.8%)
BOOTHBAY FUND MANAGEMENT, LLC	180,744	136,377	-44,367 (-24.5%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	48,400	13,400	-35,000 (-72.3%)
Pale Fire Capital SE	33,650	22,302	-11,348 (-33.7%)
XTX Topco Ltd	26,715	11,144	-15,571 (-58.3%)
Point72 Asset Management, L.P.	1,941,849	1,894,722	-47,127 (-2.4%)
DIMENSIONAL FUND ADVISORS LP	912,533	862,892	-49,641 (-5.4%)
AQR CAPITAL MANAGEMENT LLC	347,923	337,386	-10,537 (-3.0%)
IEQ CAPITAL, LLC	33,581	24,692	-8,889 (-26.5%)
Tower Research Capital LLC (TRC)	3,737	826	-2,911 (-77.9%)
Cerity Partners LLC	23,590	22,439	-1,151 (-4.9%)

Exited Positions (9)

Palumbo Wealth Management LLC

Value ($000) $407 Shares 61,276

D1 Capital Partners L.P.

Value ($000) $6,498 Shares 978,652

Scientech Research LLC

Value ($000) $90 Shares 13,502

AXQ CAPITAL, LP

Value ($000) $99 Shares 14,921

ExodusPoint Capital Management, LP

Value ($000) $182 Shares 27,380

Virtu Financial LLC

Value ($000) $0 Shares 43,269

Brevan Howard Capital Management LP

Value ($000) $122 Shares 18,400

SRS Capital Advisors, Inc.

Value ($000) $30 Shares 4,551

HRT FINANCIAL LP

Value ($000) $0 Shares 21,510

Institution	Prev Shares	Prev Value ($000)
Palumbo Wealth Management LLC	61,276	$407
D1 Capital Partners L.P.	978,652	$6,498
Scientech Research LLC	13,502	$90
AXQ CAPITAL, LP	14,921	$99
ExodusPoint Capital Management, LP	27,380	$182
Virtu Financial LLC	43,269	$0
Brevan Howard Capital Management LP	18,400	$122
SRS Capital Advisors, Inc.	4,551	$30
HRT FINANCIAL LP	21,510	$0