MADRIGAL PHARMACEUTICALS INC

Ticker: MDGL CUSIP: 558868105 Class: EQTY

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 83,862 Value ($000) $48,836 Avg Close $510.76 Range $393.61 - $615.00

Q3 2025

Shares 120,682 Value ($000) $55,352 Avg Close $373.08 Range $284.02 - $460.22

Q2 2025

Shares 10,836 Value ($000) $3,279 Avg Close $297.95 Range $265.00 - $349.00

Q1 2025

Shares 85,086 Value ($000) $28,183 Avg Close $328.59 Range $266.44 - $377.46

Q4 2024

Shares 160,782 Value ($000) $49,613 Avg Close $281.26 Range $200.63 - $368.29

Q3 2024

Shares 44,497 Value ($000) $9,443 Avg Close $255.83 Range $208.94 - $298.00

Q3 2023

Shares 68,082 Value ($000) $10 Avg Close $188.22 Range $143.75 - $239.76

Q2 2023

Shares 78,682 Value ($000) $18 Avg Close $270.85 Range $192.22 - $322.67

Q1 2023

Shares 175,382 Value ($000) $42 Avg Close $272.48 Range $222.87 - $313.93

Q4 2022

Shares 4,582 Value ($000) $1 Avg Close $97.80 Range $57.21 - $315.45

Q1 2022

Shares 4,800 Value ($000) $471 Avg Close $84.31 Range $52.33 - $105.93

Q4 2021

Shares 2,400 Value ($000) $203 Avg Close $82.16 Range $68.56 - $102.42

Q3 2021

Shares 17,111 Value ($000) $1,365 Avg Close $86.38 Range $77.60 - $105.72

Q2 2021

Shares 52,982 Value ($000) $5,161 Avg Close $118.38 Range $95.21 - $142.62

Q1 2021

Shares 34,282 Value ($000) $4,010 Avg Close $116.59 Range $105.16 - $131.99

Q4 2020

Shares 34,033 Value ($000) $3,783 Avg Close $122.23 Range $107.55 - $137.28

Q3 2020

Shares 21,782 Value ($000) $2,586 Avg Close $108.57 Range $98.65 - $125.06

Q2 2020

Shares 72,382 Value ($000) $8,197 Avg Close $98.34 Range $56.82 - $127.25

Q1 2020

Shares 26,482 Value ($000) $1,768 Avg Close $83.31 Range $60.86 - $94.74

Q4 2017

Shares 87,587 Value ($000) $8,040 Avg Close $57.12 Range $38.82 - $101.00

Q3 2017

Shares 127,287 Value ($000) $5,725 Avg Close $18.72 Range $15.15 - $49.48

Q2 2017

Shares 75,387 Value ($000) $1,226 Avg Close $15.63 Range $13.09 - $17.84

Q1 2017

Shares 57,875 Value ($000) $891 Avg Close $15.73 Range $14.78 - $16.63

Q4 2016

Shares 57,475 Value ($000) $856 Avg Close $16.07 Range $12.60 - $18.24

Q3 2016

Shares 52,987 Value ($000) $672 Avg Close $9.69 Range $6.60 - $14.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	83,862	$48,836	$510.76	$393.61 - $615.00
Q3 2025	120,682	$55,352	$373.08	$284.02 - $460.22
Q2 2025	10,836	$3,279	$297.95	$265.00 - $349.00
Q1 2025	85,086	$28,183	$328.59	$266.44 - $377.46
Q4 2024	160,782	$49,613	$281.26	$200.63 - $368.29
Q3 2024	44,497	$9,443	$255.83	$208.94 - $298.00
Q3 2023	68,082	$10	$188.22	$143.75 - $239.76
Q2 2023	78,682	$18	$270.85	$192.22 - $322.67
Q1 2023	175,382	$42	$272.48	$222.87 - $313.93
Q4 2022	4,582	$1	$97.80	$57.21 - $315.45
Q1 2022	4,800	$471	$84.31	$52.33 - $105.93
Q4 2021	2,400	$203	$82.16	$68.56 - $102.42
Q3 2021	17,111	$1,365	$86.38	$77.60 - $105.72
Q2 2021	52,982	$5,161	$118.38	$95.21 - $142.62
Q1 2021	34,282	$4,010	$116.59	$105.16 - $131.99
Q4 2020	34,033	$3,783	$122.23	$107.55 - $137.28
Q3 2020	21,782	$2,586	$108.57	$98.65 - $125.06
Q2 2020	72,382	$8,197	$98.34	$56.82 - $127.25
Q1 2020	26,482	$1,768	$83.31	$60.86 - $94.74
Q4 2017	87,587	$8,040	$57.12	$38.82 - $101.00
Q3 2017	127,287	$5,725	$18.72	$15.15 - $49.48
Q2 2017	75,387	$1,226	$15.63	$13.09 - $17.84
Q1 2017	57,875	$891	$15.73	$14.78 - $16.63
Q4 2016	57,475	$856	$16.07	$12.60 - $18.24
Q3 2016	52,987	$672	$9.69	$6.60 - $14.00