MADRIGAL PHARMACEUTICALS INC

Ticker: MDGL CUSIP: 558868105 Class: EQTY

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,300 Value ($000) $1,922 Avg Close $510.76 Range $393.61 - $615.00

Q4 2023

Shares 27,767 Value ($000) $6,425 Avg Close $174.99 Range $119.76 - $245.31

Q3 2023

Shares 50,867 Value ($000) $7,429 Avg Close $188.22 Range $143.75 - $239.76

Q2 2023

Shares 25,000 Value ($000) $5,775 Avg Close $270.85 Range $192.22 - $322.67

Q1 2023

Shares 19,000 Value ($000) $4,603 Avg Close $272.48 Range $222.87 - $313.93

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,300	$1,922	$510.76	$393.61 - $615.00
Q4 2023	27,767	$6,425	$174.99	$119.76 - $245.31
Q3 2023	50,867	$7,429	$188.22	$143.75 - $239.76
Q2 2023	25,000	$5,775	$270.85	$192.22 - $322.67
Q1 2023	19,000	$4,603	$272.48	$222.87 - $313.93