NAUTILUS BIOTECHNOLOGY INC

Ticker: NAUT CUSIP: 63909J108 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 840,000 Value ($000) $3,646 Avg Close $4.10 Range $3.36 - $5.33

Q4 2021

Shares 800,000 Value ($000) $4,144 Avg Close $5.35 Range $4.41 - $6.33

Q3 2021

Shares 800,000 Value ($000) $4,912 Avg Close $7.97 Range $6.10 - $12.38

Q2 2021

Shares 800,000 Value ($000) $8,080 Avg Close $10.83 Range $8.85 - $14.95

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	840,000	$3,646	$4.10	$3.36 - $5.33
Q4 2021	800,000	$4,144	$5.35	$4.41 - $6.33
Q3 2021	800,000	$4,912	$7.97	$6.10 - $12.38
Q2 2021	800,000	$8,080	$10.83	$8.85 - $14.95