NEUROCRINE BIOSCIENCES INC

Ticker: NBIX CUSIP: 64125C109 Class: EQTY

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015

Shares 55,000 Value ($000) $3,111 Avg Close $50.83 Range $37.76 - $58.46

Q3 2015

Shares 125,000 Value ($000) $4,973 Avg Close $48.33 Range $33.61 - $56.97

Q2 2015

Shares 145,000 Value ($000) $6,925 Avg Close $42.40 Range $32.67 - $49.49

Q1 2015

Shares 145,000 Value ($000) $5,758 Avg Close $35.77 Range $19.68 - $45.36

Q4 2014

Shares 45,000 Value ($000) $1,005 Avg Close $18.95 Range $15.20 - $24.86

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2015	55,000	$3,111	$50.83	$37.76 - $58.46
Q3 2015	125,000	$4,973	$48.33	$33.61 - $56.97
Q2 2015	145,000	$6,925	$42.40	$32.67 - $49.49
Q1 2015	145,000	$5,758	$35.77	$19.68 - $45.36
Q4 2014	45,000	$1,005	$18.95	$15.20 - $24.86