| BlackRock, Inc. | 12,830,597 | $1,819,764 |
| VANGUARD GROUP INC | 9,700,301 | $1,375,794 |
| Dodge & Cox | 5,508,042 | $781,206 |
| JPMORGAN CHASE & CO | 5,200,356 | $737,567 |
| STATE STREET CORP | 4,242,681 | $601,739 |
| AQR CAPITAL MANAGEMENT LLC | 3,271,706 | $462,652 |
| RENAISSANCE TECHNOLOGIES LLC | 2,238,797 | $317,529 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,059,282 | $291,342 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,872,240 | $266 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,744,560 | $247,431 |
| Bellevue Group AG | 1,703,304 | $241,580 |
| BNP Paribas Investment Partners S.A. | 1,395,902 | $198 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1,291,278 | $178,248 |
| NORTHERN TRUST CORP | 1,221,184 | $173,201 |
| MORGAN STANLEY | 1,209,378 | $171,527 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,184,345 | $167,976 |
| NORGES BANK | 1,146,896 | $162,664 |
| RTW INVESTMENTS, LP | 1,062,072 | $150,634 |
| TWO SIGMA INVESTMENTS, LP | 984,811 | $139,676 |
| UBS Group AG | 983,528 | $139,494 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 850,632 | $120,645 |
| TWO SIGMA ADVISERS, LP | 842,592 | $119,505 |
| ARMISTICE CAPITAL, LLC | 820,240 | $116,335 |
| Pictet Asset Management Holding SA | 776,934 | $110,305 |
| BRAIDWELL LP | 751,534 | $106,590 |
| IEQ CAPITAL, LLC | 745,113 | $105,679 |
| Bank of New York Mellon Corp | 738,676 | $104,766 |
| UBS ASSET MANAGEMENT AMERICAS INC | 722,476 | $102,469 |
| DIMENSIONAL FUND ADVISORS LP | 716,475 | $101,612 |
| Fiera Capital Corp | 637,408 | $90,404 |
| RAYMOND JAMES FINANCIAL INC | 631,422 | $89,221 |
| AMERIPRISE FINANCIAL INC | 585,677 | $83,067 |
| Swedbank AB | 584,129 | $82,847 |
| GW&K Investment Management, LLC | 576,648 | $82 |
| ALLIANCEBERNSTEIN L.P. | 555,494 | $78,786 |
| FRANKLIN RESOURCES INC | 532,759 | $75,561 |
| BANK OF AMERICA CORP /DE/ | 528,104 | $74,901 |
| PRIMECAP MANAGEMENT CO/CA/ | 507,740 | $72,013 |
| FIRST TRUST ADVISORS LP | 486,809 | $69,044 |
| Zurich Insurance Group Ltd/FI | 459,437 | $65,162 |
| JANUS HENDERSON GROUP PLC | 459,176 | $65,127 |
| MILLENNIUM MANAGEMENT LLC | 442,866 | $62,812 |
| Hood River Capital Management LLC | 389,297 | $55,214 |
| DEUTSCHE BANK AG\ | 367,944 | $52,185 |
| GOLDMAN SACHS GROUP INC | 364,535 | $51,702 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 360,711 | $51,160 |
| MARSHALL WACE, LLP | 348,843 | $49,476 |
| Invesco Ltd. | 343,421 | $48,707 |
| Allspring Global Investments Holdings, LLC | 339,432 | $47,724 |
| PERCEPTIVE ADVISORS LLC | 331,050 | $46,953 |
| Legal & General Group Plc | 330,606 | $46,890 |
| ORBIMED ADVISORS LLC | 314,240 | $44,569 |
| ROYAL BANK OF CANADA | 311,012 | $44,110 |
| Clearbridge Investments, LLC | 310,077 | $43,978 |
| Hudson Bay Capital Management LP | 305,000 | $43,258 |
| Sarissa Capital Management LP | 303,151 | $42,996 |
| RHUMBLINE ADVISERS | 297,444 | $42,186 |
| Candriam S.C.A. | 293,096 | $41,572 |
| Nuveen, LLC | 286,785 | $40,675 |
| Rockefeller Capital Management L.P. | 281,320 | $39,900 |
| Swiss National Bank | 271,800 | $38,549 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 256,085 | $36,321 |
| RENAISSANCE GROUP LLC | 252,293 | $35,783 |
| BARCLAYS PLC | 252,241 | $35,775 |
| ACADIAN ASSET MANAGEMENT LLC | 249,154 | $35 |
| Connor, Clark & Lunn Investment Management Ltd. | 246,289 | $34,931 |
| WELLS FARGO & COMPANY/MN | 242,111 | $34,339 |
| Man Group plc | 231,210 | $32,793 |
| PRINCIPAL FINANCIAL GROUP INC | 226,377 | $32,107 |
| BROWN ADVISORY INC | 225,288 | $31,953 |
| BNP PARIBAS ARBITRAGE, SA | 213,992 | $30,350 |
| Squarepoint Ops LLC | 209,706 | $29,743 |
| ENVESTNET ASSET MANAGEMENT INC | 206,731 | $29,321 |
| Sumitomo Mitsui Trust Holdings, Inc. | 202,666 | $28,744 |
| Handelsbanken Fonder AB | 200,867 | $28 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 196,821 | $27,915 |
| Susquehanna Portfolio Strategies, LLC | 184,035 | $26,102 |
| BRAUN STACEY ASSOCIATES INC | 182,262 | $25,850 |
| SEI INVESTMENTS CO | 179,397 | $25,444 |
| Soleus Capital Management, L.P. | 175,982 | $24,960 |
| NEW YORK STATE COMMON RETIREMENT FUND | 174,774 | $24,788 |
| LOOMIS SAYLES & CO L P | 169,220 | $24,000 |
| Gotham Asset Management, LLC | 168,572 | $23,909 |
| Ensign Peak Advisors, Inc | 167,307 | $23,729 |
| Amundi | 166,350 | $23,593 |
| PFM Health Sciences, LP | 163,197 | $23,146 |
| Eagle Health Investments LP | 162,800 | $23,090 |
| AMERICAN CENTURY COMPANIES INC | 158,485 | $22,478 |
| BOONE CAPITAL MANAGEMENT LLC | 151,815 | $21,532 |
| Integral Health Asset Management, LLC | 150,000 | $21,275 |
| Bridgewater Associates, LP | 149,990 | $21,273 |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 149,156 | $21,153 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 147,623 | $20,937 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 145,561 | $20,645 |
| BALYASNY ASSET MANAGEMENT L.P. | 141,101 | $20,012 |
| Freestone Grove Partners LP | 140,529 | $19,931 |
| DnB Asset Management AS | 139,457 | $19,779 |
| PKO BP BANKOWY Universal Pension Society JSC | 138,802 | $19,686 |
| Trexquant Investment LP | 137,186 | $19,457 |
| SG Americas Securities, LLC | 134,530 | $19 |
| 618 other institutions | 10,862,640 | $1,374,185 |