PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

COMERICA BANK's Holding History (CIK: 0000901541)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 17 Value ($000) $5 Avg Close $186.22 Range $50.31 - $317.72

Q1 2025

Shares 40 Value ($000) $2 Avg Close $62.45 Range $30.01 - $91.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	17	$5	$186.22	$50.31 - $317.72
Q1 2025	40	$2	$62.45	$30.01 - $91.83