PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 66,230 Value ($000) $19,521 Avg Close $186.22 Range $50.31 - $317.72

Q2 2024

Shares 75,433 Value ($000) $3,120 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 12,104 Value ($000) $1 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 80,804 Value ($000) $2 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	66,230	$19,521	$186.22	$50.31 - $317.72
Q2 2024	75,433	$3,120	$47.26	$33.01 - $63.00
Q1 2024	12,104	$1	$44.86	$20.50 - $67.21
Q4 2023	80,804	$2	$18.01	$13.01 - $27.60