PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 57,901 Value ($000) $3,069 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 109,757 Value ($000) $4,615 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 140,660 Value ($000) $5,327 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 91,583 Value ($000) $7,048 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 152,307 Value ($000) $8,764 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 283,424 Value ($000) $11,722 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 177,139 Value ($000) $10,809 Avg Close $44.86 Range $20.50 - $67.21

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	57,901	$3,069	$48.49	$37.19 - $61.03
Q2 2025	109,757	$4,615	$38.08	$26.70 - $46.93
Q1 2025	140,660	$5,327	$62.45	$30.01 - $91.83
Q4 2024	91,583	$7,048	$72.36	$55.33 - $86.93
Q3 2024	152,307	$8,764	$54.02	$38.99 - $63.93
Q2 2024	283,424	$11,722	$47.26	$33.01 - $63.00
Q1 2024	177,139	$10,809	$44.86	$20.50 - $67.21