PRELUDE THERAPEUTICS INC

Ticker: PRLD CUSIP: 74065P101 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 122,752 Value ($000) $356 Avg Close $1.69 Range $1.15 - $4.22

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	122,752	$356	$1.69	$1.15 - $4.22