| ORBIMED ADVISORS LLC | 10,909,256 | $31,637 |
| BAKER BROS. ADVISORS LP | 10,123,824 | $29,359 |
| VANGUARD GROUP INC | 1,413,986 | $4,101 |
| Kynam Capital Management, LP | 788,867 | $2,288 |
| TWO SIGMA INVESTMENTS, LP | 788,695 | $2,287 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 755,956 | $2 |
| ACADIAN ASSET MANAGEMENT LLC | 535,703 | $2 |
| MORGAN STANLEY | 334,916 | $971 |
| MARSHALL WACE, LLP | 273,883 | $794 |
| GEODE CAPITAL MANAGEMENT, LLC | 272,886 | $792 |
| RENAISSANCE TECHNOLOGIES LLC | 271,300 | $787 |
| BlackRock, Inc. | 266,280 | $772 |
| TWO SIGMA ADVISERS, LP | 237,300 | $688 |
| TD Asset Management Inc | 160,652 | $466 |
| MILLENNIUM MANAGEMENT LLC | 150,997 | $438 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,909 | $394 |
| STATE STREET CORP | 127,292 | $369 |
| SPHERA FUNDS MANAGEMENT LTD. | 122,752 | $356 |
| GOLDMAN SACHS GROUP INC | 117,477 | $341 |
| JANE STREET GROUP, LLC | 111,040 | $322 |
| OMERS ADMINISTRATION Corp | 73,000 | $212 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,546 | $200 |
| Point72 Asset Management, L.P. | 59,168 | $172 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,500 | $155 |
| XTX Topco Ltd | 50,159 | $145 |
| NORTHERN TRUST CORP | 50,120 | $145 |
| Focus Partners Wealth | 50,007 | $145 |
| Connor, Clark & Lunn Investment Management Ltd. | 46,090 | $134 |
| Cerity Partners LLC | 32,953 | $96 |
| Qube Research & Technologies Ltd | 21,551 | $62 |
| PRUDENTIAL FINANCIAL INC | 15,520 | $45 |
| HSBC HOLDINGS PLC | 13,652 | $39 |
| BANK OF AMERICA CORP /DE/ | 9,808 | $28 |
| BARCLAYS PLC | 8,602 | $25 |
| FMR LLC | 6,152 | $18 |
| SBI Securities Co., Ltd. | 2,741 | $8 |
| CALDWELL SUTTER CAPITAL, INC. | 2,000 | $6 |
| UBS Group AG | 1,857 | $5 |
| ROYAL BANK OF CANADA | 1,742 | $5 |
| NISA INVESTMENT ADVISORS, LLC | 1,634 | $5 |
| PNC Financial Services Group, Inc. | 1,171 | $3 |
| CWM, LLC | 692 | $0 |
| GROUP ONE TRADING, L.P. | 500 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 95 | $0 |
| JPMORGAN CHASE & CO | 62 | $0 |
| Optiver Holding B.V. | 20 | $0 |
| CITIGROUP INC | 1 | $0 |
| IFP Advisors, Inc | 1 | $0 |