PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,167 Value ($000) $713 Avg Close $81.85 Range $62.24 - $96.54

Q2 2025

Shares 173,134 Value ($000) $9,569 Avg Close $47.99 Range $39.60 - $57.70

Q1 2025

Shares 323,567 Value ($000) $15,648 Avg Close $41.90 Range $33.70 - $60.60

Q4 2024

Shares 221,167 Value ($000) $8,537 Avg Close $43.60 Range $33.31 - $48.89

Q3 2024

Shares 144,167 Value ($000) $6,488 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 297,467 Value ($000) $10,307 Avg Close $29.29 Range $24.22 - $35.96

Q1 2024

Shares 32,567 Value ($000) $1 Avg Close $27.21 Range $21.43 - $33.34

Q4 2023

Shares 213,967 Value ($000) $5 Avg Close $17.50 Range $13.72 - $23.88

Q3 2023

Shares 226,268 Value ($000) $4 Avg Close $19.40 Range $16.33 - $26.81

Q2 2023

Shares 390,267 Value ($000) $11 Avg Close $25.03 Range $17.64 - $30.10

Q1 2023

Shares 690,867 Value ($000) $16 Avg Close $16.79 Range $10.62 - $25.69

Q4 2022

Shares 258,867 Value ($000) $3 Avg Close $8.44 Range $7.24 - $11.46

Q3 2022

Shares 399,767 Value ($000) $3,370 Avg Close $9.46 Range $7.68 - $11.97

Q2 2022

Shares 322,867 Value ($000) $2,554 Avg Close $12.09 Range $6.91 - $25.76

Q1 2022

Shares 19,467 Value ($000) $461 Avg Close $28.17 Range $22.56 - $37.05

Q4 2020

Shares 35,797 Value ($000) $722 Avg Close $21.52 Range $17.44 - $25.65

Q3 2020

Shares 336,700 Value ($000) $6,582 Avg Close $18.76 Range $14.16 - $23.25

Q2 2020

Shares 532,300 Value ($000) $9,400 Avg Close $12.55 Range $6.00 - $19.67

Q1 2020

Shares 575,400 Value ($000) $4,062 Avg Close $7.49 Range $5.30 - $9.30

Q4 2019

Shares 618,124 Value ($000) $4,358 Avg Close $9.93 Range $4.47 - $13.77

Q3 2019

Shares 555,100 Value ($000) $6,667 Avg Close $12.60 Range $8.26 - $16.67

Q2 2019

Shares 512,300 Value ($000) $6,204 Avg Close $11.06 Range $8.88 - $13.14

Q1 2019

Shares 405,000 Value ($000) $5,091 Avg Close $8.83 Range $6.38 - $14.36

Q4 2018

Shares 339,800 Value ($000) $2,287 Avg Close $7.93 Range $5.49 - $10.50

Q3 2018

Shares 537,200 Value ($000) $5,528 Avg Close $8.61 Range $6.57 - $11.90

Q2 2018

Shares 478,300 Value ($000) $3,214 Avg Close $7.68 Range $5.50 - $9.44

Q1 2018

Shares 52,200 Value ($000) $448 Avg Close $18.83 Range $7.85 - $23.97

Q2 2017

Shares 25,989 Value ($000) $294 Avg Close $10.69 Range $8.00 - $14.85

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,167	$713	$81.85	$62.24 - $96.54
Q2 2025	173,134	$9,569	$47.99	$39.60 - $57.70
Q1 2025	323,567	$15,648	$41.90	$33.70 - $60.60
Q4 2024	221,167	$8,537	$43.60	$33.31 - $48.89
Q3 2024	144,167	$6,488	$40.40	$32.50 - $48.00
Q2 2024	297,467	$10,307	$29.29	$24.22 - $35.96
Q1 2024	32,567	$1	$27.21	$21.43 - $33.34
Q4 2023	213,967	$5	$17.50	$13.72 - $23.88
Q3 2023	226,268	$4	$19.40	$16.33 - $26.81
Q2 2023	390,267	$11	$25.03	$17.64 - $30.10
Q1 2023	690,867	$16	$16.79	$10.62 - $25.69
Q4 2022	258,867	$3	$8.44	$7.24 - $11.46
Q3 2022	399,767	$3,370	$9.46	$7.68 - $11.97
Q2 2022	322,867	$2,554	$12.09	$6.91 - $25.76
Q1 2022	19,467	$461	$28.17	$22.56 - $37.05
Q4 2020	35,797	$722	$21.52	$17.44 - $25.65
Q3 2020	336,700	$6,582	$18.76	$14.16 - $23.25
Q2 2020	532,300	$9,400	$12.55	$6.00 - $19.67
Q1 2020	575,400	$4,062	$7.49	$5.30 - $9.30
Q4 2019	618,124	$4,358	$9.93	$4.47 - $13.77
Q3 2019	555,100	$6,667	$12.60	$8.26 - $16.67
Q2 2019	512,300	$6,204	$11.06	$8.88 - $13.14
Q1 2019	405,000	$5,091	$8.83	$6.38 - $14.36
Q4 2018	339,800	$2,287	$7.93	$5.49 - $10.50
Q3 2018	537,200	$5,528	$8.61	$6.57 - $11.90
Q2 2018	478,300	$3,214	$7.68	$5.50 - $9.44
Q1 2018	52,200	$448	$18.83	$7.85 - $23.97
Q2 2017	25,989	$294	$10.69	$8.00 - $14.85