PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 21,700 Value ($000) $1,895 Avg Close $81.85 Range $62.24 - $96.54

Q1 2023

Shares 301,000 Value ($000) $6,923 Avg Close $16.79 Range $10.62 - $25.69

Q1 2020

Shares 66,909 Value ($000) $472 Avg Close $7.49 Range $5.30 - $9.30

Q4 2019

Shares 191,209 Value ($000) $1,348 Avg Close $9.93 Range $4.47 - $13.77

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	21,700	$1,895	$81.85	$62.24 - $96.54
Q1 2023	301,000	$6,923	$16.79	$10.62 - $25.69
Q1 2020	66,909	$472	$7.49	$5.30 - $9.30
Q4 2019	191,209	$1,348	$9.93	$4.47 - $13.77