PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021

Shares 260,379 Value ($000) $4,614 Avg Close $42.63 Range $12.80 - $50.54

Q2 2021

Shares 302,965 Value ($000) $13,597 Avg Close $33.01 Range $24.14 - $45.93

Q1 2021

Shares 202,134 Value ($000) $5,235 Avg Close $25.31 Range $18.82 - $32.10

Q1 2020

Shares 526,075 Value ($000) $3,714 Avg Close $7.49 Range $5.30 - $9.30

Q4 2019

Shares 630,000 Value ($000) $4,442 Avg Close $9.93 Range $4.47 - $13.77

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2021	260,379	$4,614	$42.63	$12.80 - $50.54
Q2 2021	302,965	$13,597	$33.01	$24.14 - $45.93
Q1 2021	202,134	$5,235	$25.31	$18.82 - $32.10
Q1 2020	526,075	$3,714	$7.49	$5.30 - $9.30
Q4 2019	630,000	$4,442	$9.93	$4.47 - $13.77