PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

EcoR1 Capital, LLC's Holding History (CIK: 0001587114)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 381,711 Value ($000) $9,039 Avg Close $28.17 Range $22.56 - $37.05

Q4 2021

Shares 2,639,706 Value ($000) $90,278 Avg Close $31.61 Range $17.26 - $38.11

Q3 2021

Shares 1,443,800 Value ($000) $25,584 Avg Close $42.63 Range $12.80 - $50.54

Q1 2018

Shares 1,083,567 Value ($000) $9,308 Avg Close $18.83 Range $7.85 - $23.97

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	381,711	$9,039	$28.17	$22.56 - $37.05
Q4 2021	2,639,706	$90,278	$31.61	$17.26 - $38.11
Q3 2021	1,443,800	$25,584	$42.63	$12.80 - $50.54
Q1 2018	1,083,567	$9,308	$18.83	$7.85 - $23.97