PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q3 2019

Shares 636,600 Value ($000) $6,853 Avg Close $10.80 Range $8.45 - $13.35

Q2 2019

Shares 624,249 Value ($000) $7,934 Avg Close $23.03 Range $12.22 - $36.75

Q1 2019

Shares 1,880,000 Value ($000) $72,925 Avg Close $30.54 Range $19.86 - $43.90

Q4 2018

Shares 2,598,883 Value ($000) $52,887 Avg Close $30.01 Range $17.60 - $47.14

Q3 2018

Shares 2,705,181 Value ($000) $124,033 Avg Close $48.21 Range $40.45 - $60.95

Q2 2018

Shares 2,732,881 Value ($000) $161,650 Avg Close $57.95 Range $47.00 - $68.90

Q1 2018

Shares 2,641,661 Value ($000) $179,765 Avg Close $74.88 Range $56.15 - $101.50

Q4 2017

Shares 2,184,535 Value ($000) $215,941 Avg Close $111.90 Range $92.36 - $136.90

Q3 2017

Shares 2,425,735 Value ($000) $290,482 Avg Close $93.01 Range $71.14 - $120.85

Q2 2017

Shares 2,425,735 Value ($000) $212,009 Avg Close $55.94 Range $28.35 - $92.00

Q1 2017

Shares 2,245,925 Value ($000) $83,548 Avg Close $36.49 Range $28.95 - $45.44

Q4 2016

Shares 2,275,825 Value ($000) $69,868 Avg Close $43.24 Range $29.85 - $68.05

Q3 2016

Shares 2,383,525 Value ($000) $159,815 Avg Close $50.56 Range $28.14 - $73.27

Q2 2016

Shares 2,964,025 Value ($000) $88,298 Avg Close $31.26 Range $19.74 - $39.67

Q1 2016

Shares 2,753,425 Value ($000) $80,868 Avg Close $45.19 Range $25.20 - $77.99

Q4 2015

Shares 2,238,825 Value ($000) $175,524 Avg Close $78.49 Range $56.11 - $94.93

Q3 2015

Shares 1,195,500 Value ($000) $90,093 Avg Close $94.57 Range $70.39 - $119.36

Q2 2015

Shares 940,800 Value ($000) $109,838 Avg Close $181.09 Range $112.32 - $244.90

Q1 2015

Shares 370,200 Value ($000) $87,408 Avg Close $213.77 Range $183.50 - $252.92

Q4 2014

Shares 250,900 Value ($000) $47,488 Avg Close $221.87 Range $181.60 - $255.43

Q3 2014

Shares 212,900 Value ($000) $50,792 Avg Close $205.34 Range $57.25 - $279.37

Q2 2014

Shares 218,100 Value ($000) $14,395 Avg Close $71.11 Range $53.63 - $118.22

Q2 2013

Shares 295,000 Value ($000) $13,089 Avg Close $35.25 Range $27.40 - $45.69

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2019	636,600	$6,853	$10.80	$8.45 - $13.35
Q2 2019	624,249	$7,934	$23.03	$12.22 - $36.75
Q1 2019	1,880,000	$72,925	$30.54	$19.86 - $43.90
Q4 2018	2,598,883	$52,887	$30.01	$17.60 - $47.14
Q3 2018	2,705,181	$124,033	$48.21	$40.45 - $60.95
Q2 2018	2,732,881	$161,650	$57.95	$47.00 - $68.90
Q1 2018	2,641,661	$179,765	$74.88	$56.15 - $101.50
Q4 2017	2,184,535	$215,941	$111.90	$92.36 - $136.90
Q3 2017	2,425,735	$290,482	$93.01	$71.14 - $120.85
Q2 2017	2,425,735	$212,009	$55.94	$28.35 - $92.00
Q1 2017	2,245,925	$83,548	$36.49	$28.95 - $45.44
Q4 2016	2,275,825	$69,868	$43.24	$29.85 - $68.05
Q3 2016	2,383,525	$159,815	$50.56	$28.14 - $73.27
Q2 2016	2,964,025	$88,298	$31.26	$19.74 - $39.67
Q1 2016	2,753,425	$80,868	$45.19	$25.20 - $77.99
Q4 2015	2,238,825	$175,524	$78.49	$56.11 - $94.93
Q3 2015	1,195,500	$90,093	$94.57	$70.39 - $119.36
Q2 2015	940,800	$109,838	$181.09	$112.32 - $244.90
Q1 2015	370,200	$87,408	$213.77	$183.50 - $252.92
Q4 2014	250,900	$47,488	$221.87	$181.60 - $255.43
Q3 2014	212,900	$50,792	$205.34	$57.25 - $279.37
Q2 2014	218,100	$14,395	$71.11	$53.63 - $118.22
Q2 2013	295,000	$13,089	$35.25	$27.40 - $45.69