PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018

Shares 60,000 Value ($000) $4,083 Avg Close $74.88 Range $56.15 - $101.50

Q4 2017

Shares 35,000 Value ($000) $3,460 Avg Close $111.90 Range $92.36 - $136.90

Q1 2015

Shares 13,796 Value ($000) $3,257 Avg Close $213.77 Range $183.50 - $252.92

Q4 2014

Shares 20,296 Value ($000) $3,841 Avg Close $221.87 Range $181.60 - $255.43

Q3 2014

Shares 30,296 Value ($000) $7,228 Avg Close $205.34 Range $57.25 - $279.37

Q2 2014

Shares 25,000 Value ($000) $1,650 Avg Close $71.11 Range $53.63 - $118.22

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2018	60,000	$4,083	$74.88	$56.15 - $101.50
Q4 2017	35,000	$3,460	$111.90	$92.36 - $136.90
Q1 2015	13,796	$3,257	$213.77	$183.50 - $252.92
Q4 2014	20,296	$3,841	$221.87	$181.60 - $255.43
Q3 2014	30,296	$7,228	$205.34	$57.25 - $279.37
Q2 2014	25,000	$1,650	$71.11	$53.63 - $118.22