RHYTHM PHARMACEUTICALS INC

Ticker: RYTM CUSIP: 76243J105 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 499,975 Value ($000) $53,517 Avg Close $106.08 Range $95.27 - $122.20

Q3 2025

Shares 499,975 Value ($000) $50,492 Avg Close $92.84 Range $62.84 - $106.52

Q2 2025

Shares 409,742 Value ($000) $25,892 Avg Close $61.23 Range $45.91 - $69.89

Q1 2025

Shares 277,533 Value ($000) $14,701 Avg Close $55.48 Range $47.86 - $62.14

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	499,975	$53,517	$106.08	$95.27 - $122.20
Q3 2025	499,975	$50,492	$92.84	$62.84 - $106.52
Q2 2025	409,742	$25,892	$61.23	$45.91 - $69.89
Q1 2025	277,533	$14,701	$55.48	$47.86 - $62.14