SAGIMET BIOSCIENCES INC

Institution	Shares	Value ($000)
RB Capital Management, LLC	97,000	$574
Pale Fire Capital SE	221,875	$1,314
SHERBROOKE PARK ADVISERS LLC	10,135	$60
683 Capital Management, LLC	126,349	$748
HAMILTON LANE ADVISORS LLC	11,095	$66
MARSHALL WACE, LLP	780,446	$4,620
Hudson Bay Capital Management LP	304,472	$1,802
Verition Fund Management LLC	154,670	$916
Point72 Asset Management, L.P.	175,830	$1,041
Lighthouse Investment Partners, LLC	22,740	$135
OMERS ADMINISTRATION Corp	53,400	$316
Kestra Advisory Services, LLC	66,014	$391
Wedmont Private Capital	10,794	$60
Cresset Asset Management, LLC	20,079	$119
China Universal Asset Management Co., Ltd.	5,052	$30
CITIGROUP INC	17,976	$106
Vanguard Personalized Indexing Management, LLC	10,078	$60
SIMPLEX TRADING, LLC	14,227	$84
VSM Wealth Advisory, LLC	1,500	$9
Mirae Asset Global Investments Co., Ltd.	1,506	$9

Increased Positions (26)

Affinity Asset Advisors, LLC

Value ($000) $6,798 (+183.1%) Shares 1,148,245 (+228.1%)

FNY Investment Advisers, LLC

Value ($000) $1 (+11.3%) Shares 142,881 (+29.1%)

XTX Topco Ltd

Value ($000) $543 (+32.5%) Shares 91,737 (+53.6%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $2,028 (+83.1%) Shares 342,500 (+112.2%)

BlackRock, Inc.

Value ($000) $4,819 (+14.6%) Shares 813,953 (+32.8%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $1,060 (+374.5%) Shares 179,024 (+449.8%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $805 (+363.3%) Shares 136,039 (+437.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $746 (+615.4%) Shares 125,946 (+729.0%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $445 (+18060.3%) Shares 75,126 (+20943.7%)

JANE STREET GROUP, LLC

Value ($000) $547 (+521.2%) Shares 92,436 (+619.9%)

Squarepoint Ops LLC

Value ($000) $502 (+108.5%) Shares 84,733 (+141.6%)

VANGUARD GROUP INC

Value ($000) $7,457 (-9.7%) Shares 1,259,550 (+4.7%)

CITADEL ADVISORS LLC

Value ($000) $374 (+442.5%) Shares 63,119 (+528.6%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $1,752 (-9.9%) Shares 295,856 (+4.5%)

LANDSCAPE CAPITAL MANAGEMENT, L.L.C.

Value ($000) $153 (-1.5%) Shares 25,901 (+14.1%)

RAYMOND JAMES FINANCIAL INC

Value ($000) $1,695 (-11.2%) Shares 286,250 (+2.9%)

Mariner, LLC

Value ($000) $190 (+10.4%) Shares 32,100 (+27.9%)

STATE STREET CORP

Value ($000) $695 (-8.3%) Shares 117,388 (+6.2%)

LPL Financial LLC

Value ($000) $122 (+13.3%) Shares 20,574 (+31.3%)

Qube Research & Technologies Ltd

Value ($000) $659 (-10.1%) Shares 111,349 (+4.2%)

Institution	Prev Shares	Curr Shares	Change
Affinity Asset Advisors, LLC	350,000	1,148,245	+798,245 (+228.1%)
FNY Investment Advisers, LLC	110,650	142,881	+32,231 (+29.1%)
XTX Topco Ltd	59,734	91,737	+32,003 (+53.6%)
RENAISSANCE TECHNOLOGIES LLC	161,400	342,500	+181,100 (+112.2%)
BlackRock, Inc.	612,717	813,953	+201,236 (+32.8%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	32,561	179,024	+146,463 (+449.8%)
DIMENSIONAL FUND ADVISORS LP	25,334	136,039	+110,705 (+437.0%)
GOLDMAN SACHS GROUP INC	15,192	125,946	+110,754 (+729.0%)
BNP PARIBAS ARBITRAGE, SA	357	75,126	+74,769 (+20943.7%)
JANE STREET GROUP, LLC	12,841	92,436	+79,595 (+619.9%)
Squarepoint Ops LLC	35,065	84,733	+49,668 (+141.6%)
VANGUARD GROUP INC	1,203,231	1,259,550	+56,319 (+4.7%)
CITADEL ADVISORS LLC	10,041	63,119	+53,078 (+528.6%)
GEODE CAPITAL MANAGEMENT, LLC	283,213	295,856	+12,643 (+4.5%)
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	22,703	25,901	+3,198 (+14.1%)
RAYMOND JAMES FINANCIAL INC	278,246	286,250	+8,004 (+2.9%)
Mariner, LLC	25,100	32,100	+7,000 (+27.9%)
STATE STREET CORP	110,488	117,388	+6,900 (+6.2%)
LPL Financial LLC	15,675	20,574	+4,899 (+31.3%)
Qube Research & Technologies Ltd	106,846	111,349	+4,503 (+4.2%)

Decreased Positions (18)

Blue Owl Capital Holdings LP

Value ($000) $7,364 (-19.2%) Shares 1,243,877 (-6.4%)

DUMAC, INC.

Value ($000) $421 (-26.3%) Shares 71,192 (-5.1%)

AlphaQuest LLC

Value ($000) $37 (-95.5%) Shares 6,174 (-94.7%)

Woodline Partners LP

Value ($000) $5,926 (-42.5%) Shares 1,000,943 (-33.3%)

GSA CAPITAL PARTNERS LLP

Value ($000) $0 (-74.5%) Shares 25,196 (-70.4%)

D. E. Shaw & Co., Inc.

Value ($000) $2,874 (-40.3%) Shares 485,496 (-30.8%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $3,475 (-34.8%) Shares 586,947 (-24.4%)

MORGAN STANLEY

Value ($000) $528 (-68.7%) Shares 89,244 (-63.7%)

UBS Group AG

Value ($000) $1,194 (-43.2%) Shares 201,759 (-34.2%)

BARCLAYS PLC

Value ($000) $174 (+9.6%) Shares 29,338 (-48.7%)

BANK OF AMERICA CORP /DE/

Value ($000) $58 (-66.8%) Shares 9,876 (-61.6%)

Man Group plc

Value ($000) $211 (-34.5%) Shares 35,606 (-24.2%)

Jasper Ridge Partners, L.P.

Value ($000) $76 (-41.6%) Shares 12,865 (-32.3%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $252 (-28.3%) Shares 42,532 (-16.9%)

Jefferies Financial Group Inc.

Value ($000) $78 (-18.0%) Shares 13,205 (-5.0%)

FEDERATED HERMES, INC.

Value ($000) $2 (-59.8%) Shares 262 (-53.5%)

FMR LLC

Value ($000) $1 (-35.9%) Shares 133 (-25.7%)

SBI Securities Co., Ltd.

Value ($000) $0 (-42.5%) Shares 24 (-33.3%)

Institution	Prev Shares	Curr Shares	Change
Blue Owl Capital Holdings LP	1,328,351	1,243,877	-84,474 (-6.4%)
DUMAC, INC.	75,000	71,192	-3,808 (-5.1%)
AlphaQuest LLC	117,259	6,174	-111,085 (-94.7%)
Woodline Partners LP	1,501,357	1,000,943	-500,414 (-33.3%)
GSA CAPITAL PARTNERS LLP	85,248	25,196	-60,052 (-70.4%)
D. E. Shaw & Co., Inc.	701,241	485,496	-215,745 (-30.8%)
MILLENNIUM MANAGEMENT LLC	776,377	586,947	-189,430 (-24.4%)
MORGAN STANLEY	246,077	89,244	-156,833 (-63.7%)
UBS Group AG	306,766	201,759	-105,007 (-34.2%)
BARCLAYS PLC	57,230	29,338	-27,892 (-48.7%)
BANK OF AMERICA CORP /DE/	25,708	9,876	-15,832 (-61.6%)
Man Group plc	46,946	35,606	-11,340 (-24.2%)
Jasper Ridge Partners, L.P.	19,000	12,865	-6,135 (-32.3%)
TWO SIGMA INVESTMENTS, LP	51,191	42,532	-8,659 (-16.9%)
Jefferies Financial Group Inc.	13,900	13,205	-695 (-5.0%)
FEDERATED HERMES, INC.	563	262	-301 (-53.5%)
FMR LLC	179	133	-46 (-25.7%)
SBI Securities Co., Ltd.	36	24	-12 (-33.3%)

Exited Positions (10)

READYSTATE ASSET MANAGEMENT LP

Value ($000) $2,232 Shares 325,359

Schonfeld Strategic Advisors LLC

Value ($000) $3,593 Shares 523,774

ORG Wealth Partners, LLC

Value ($000) $122 Shares 17,791

Graham Capital Management, L.P.

Value ($000) $336 Shares 49,051

BAILARD, INC.

Value ($000) $199 Shares 29,029

STIFEL FINANCIAL CORP

Value ($000) $70 Shares 10,155

US BANCORP \DE\

Value ($000) $7 Shares 1,000

Tower Research Capital LLC (TRC)

Value ($000) $4 Shares 541

Rise Advisors, LLC

Value ($000) $2 Shares 306

Farther Finance Advisors, LLC

Value ($000) $0 Shares 39

Institution	Prev Shares	Prev Value ($000)
READYSTATE ASSET MANAGEMENT LP	325,359	$2,232
Schonfeld Strategic Advisors LLC	523,774	$3,593
ORG Wealth Partners, LLC	17,791	$122
Graham Capital Management, L.P.	49,051	$336
BAILARD, INC.	29,029	$199
STIFEL FINANCIAL CORP	10,155	$70
US BANCORP \DE\	1,000	$7
Tower Research Capital LLC (TRC)	541	$4
Rise Advisors, LLC	306	$2
Farther Finance Advisors, LLC	39	$0