| Corvex Management LP | 3,058,629 | $397,805 |
| Casdin Capital, LLC | 3,007,164 | $391,112 |
| BlackRock, Inc. | 1,560,094 | $202,906 |
| GOLDMAN SACHS GROUP INC | 1,220,502 | $158,738 |
| VANGUARD GROUP INC | 1,189,069 | $154,650 |
| FRANKLIN RESOURCES INC | 1,092,988 | $142,154 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,018,261 | $132,435 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 920,587 | $119,732 |
| ORACLE INVESTMENT MANAGEMENT INC | 884,654 | $115,058 |
| FMR LLC | 832,738 | $108,306 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 809,210 | $105,246 |
| Invesco Ltd. | 786,466 | $102,288 |
| ARK Investment Management LLC | 604,561 | $78,629 |
| Zweig-DiMenna Associates LLC | 597,825 | $77,753 |
| LORD, ABBETT & CO. LLC | 518,304 | $67 |
| MORGAN STANLEY | 506,091 | $65,822 |
| RAYMOND JAMES FINANCIAL INC | 505,341 | $65,532 |
| GEODE CAPITAL MANAGEMENT, LLC | 504,567 | $65,635 |
| STATE STREET CORP | 456,258 | $59,341 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 413,991 | $54 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 395,323 | $51,416 |
| WELLINGTON MANAGEMENT GROUP LLP | 384,750 | $50,041 |
| Sumitomo Mitsui Trust Holdings, Inc. | 381,725 | $49,647 |
| Nikko Asset Management Americas, Inc. | 381,725 | $49,647 |
| JENNISON ASSOCIATES LLC | 302,149 | $39,297 |
| Capital International Investors | 283,248 | $36,839 |
| FRED ALGER MANAGEMENT, LLC | 266,636 | $34,679 |
| UBS ASSET MANAGEMENT AMERICAS INC | 258,745 | $33,652 |
| GAGNON SECURITIES LLC | 253,534 | $32,975 |
| ALLIANCEBERNSTEIN L.P. | 253,454 | $32,964 |
| Bank of New York Mellon Corp | 227,586 | $29,600 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 227,284 | $29,561 |
| Assenagon Asset Management S.A. | 205,895 | $26,779 |
| Science & Technology Partners, L.P. | 201,264 | $26,176 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 198,926 | $25,872 |
| OBERWEIS ASSET MANAGEMENT INC/ | 198,770 | $25,852 |
| NORTHERN TRUST CORP | 198,621 | $25,833 |
| Alamea Verwaltungs GmbH | 185,989 | $21,116 |
| CITADEL ADVISORS LLC | 182,351 | $23,717 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,030 | $23,025 |
| NEXT CENTURY GROWTH INVESTORS LLC | 173,411 | $22,554 |
| T. Rowe Price Investment Management, Inc. | 136,488 | $18 |
| ASHFORD CAPITAL MANAGEMENT INC | 132,326 | $17,210 |
| BANK OF AMERICA CORP /DE/ | 132,150 | $17,187 |
| Gagnon Advisors, LLC | 127,062 | $16,526 |
| Capital Research Global Investors | 122,666 | $15,954 |
| AMERIPRISE FINANCIAL INC | 117,057 | $15,225 |
| DIMENSIONAL FUND ADVISORS LP | 109,188 | $14,198 |
| Telemark Asset Management, LLC | 100,000 | $13,006 |
| UBS Group AG | 89,190 | $11,600 |
| Palisades Investment Partners, LLC | 87,164 | $11,337 |
| PRINCIPAL FINANCIAL GROUP INC | 81,963 | $10,660 |
| Voya Investment Management LLC | 80,081 | $10,415 |
| ROYCE & ASSOCIATES LP | 75,783 | $9,856 |
| Qube Research & Technologies Ltd | 75,408 | $9,808 |
| Russell Investments Group, Ltd. | 74,895 | $9,741 |
| CASTLEARK MANAGEMENT LLC | 74,016 | $9,627 |
| Ensign Peak Advisors, Inc | 73,007 | $9,495 |
| FARALLON CAPITAL MANAGEMENT LLC | 70,000 | $9,104 |
| AXIOM INVESTORS LLC /DE | 68,855 | $8,955 |
| NORGES BANK | 68,000 | $8,844 |
| MILLENNIUM MANAGEMENT LLC | 65,955 | $8,578 |
| SG Americas Securities, LLC | 63,181 | $8 |
| Trexquant Investment LP | 62,194 | $8,089 |
| FIRST TRUST ADVISORS LP | 62,050 | $8,070 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 61,911 | $8,052 |
| Impax Asset Management Group plc | 60,000 | $7,804 |
| POLEN CAPITAL MANAGEMENT LLC | 59,861 | $7,786 |
| Legal Advantage Investments, Inc. | 59,650 | $7,758 |
| BNP Paribas Investment Partners S.A. | 58,458 | $8 |
| RA CAPITAL MANAGEMENT, L.P. | 58,044 | $7,549 |
| RENAISSANCE TECHNOLOGIES LLC | 57,316 | $7,455 |
| Portolan Capital Management, LLC | 55,776 | $7,254 |
| RENAISSANCE GROUP LLC | 55,103 | $7,167 |
| ARDSLEY ADVISORY PARTNERS LP | 55,000 | $7,153 |
| Prosight Management, LP | 55,000 | $7,153 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 54,038 | $7,028 |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,027 | $6,637 |
| Pentwater Capital Management LP | 50,000 | $6,503 |
| Calamos Advisors LLC | 46,886 | $6,098 |
| Jump Financial, LLC | 46,200 | $6,009 |
| WELLS FARGO & COMPANY/MN | 42,911 | $5,581 |
| Nuveen, LLC | 42,625 | $5,544 |
| Lisanti Capital Growth, LLC | 41,128 | $5,349 |
| Connor, Clark & Lunn Investment Management Ltd. | 41,041 | $5,338 |
| EFG International AG | 40,826 | $5,311 |
| Swiss National Bank | 39,600 | $5,150 |
| Parkman Healthcare Partners LLC | 39,272 | $5,108 |
| Slow Capital, Inc. | 38,714 | $5,035 |
| RBF Capital, LLC | 37,340 | $4,856 |
| TD Asset Management Inc | 37,016 | $4,814 |
| SEI INVESTMENTS CO | 36,869 | $4,795 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 34,704 | $4,514 |
| BARCLAYS PLC | 33,936 | $4,414 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 31,973 | $4,158 |
| Granahan Investment Management, LLC | 30,910 | $4,020 |
| NIA IMPACT ADVISORS, LLC | 30,632 | $3,984 |
| JANE STREET GROUP, LLC | 29,625 | $3,853 |
| JPMORGAN CHASE & CO | 27,148 | $3,531 |
| VICTORY CAPITAL MANAGEMENT INC | 26,975 | $3,508 |
| 182 other institutions | 987,916 | $118,582 |