SEPTERNA INC

Ticker: SEPN CUSIP: 81734D104 Class: Common Stock

ROYAL BANK OF CANADA's Holding History (CIK: 0001000275)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 628 Value ($000) $18 Avg Close $23.88 Range $17.55 - $30.50

Q3 2025

Shares 1,083 Value ($000) $20 Avg Close $13.12 Range $10.30 - $18.99

Q2 2025

Shares 1,840 Value ($000) $19 Avg Close $8.24 Range $4.66 - $11.36

Q1 2025

Shares 802 Value ($000) $4 Avg Close $11.42 Range $4.17 - $23.85

Q4 2024

Shares 1,398 Value ($000) $32 Avg Close $23.65 Range $18.62 - $28.99

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	628	$18	$23.88	$17.55 - $30.50
Q3 2025	1,083	$20	$13.12	$10.30 - $18.99
Q2 2025	1,840	$19	$8.24	$4.66 - $11.36
Q1 2025	802	$4	$11.42	$4.17 - $23.85
Q4 2024	1,398	$32	$23.65	$18.62 - $28.99