SEPTERNA INC

Ticker: SEPN CUSIP: 81734D104 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,000,000 Value ($000) $55,760 Avg Close $23.88 Range $17.55 - $30.50

Q3 2025

Shares 2,202,514 Value ($000) $41,429 Avg Close $13.12 Range $10.30 - $18.99

Q2 2025

Shares 2,202,514 Value ($000) $23,281 Avg Close $8.24 Range $4.66 - $11.36

Q1 2025

Shares 2,202,514 Value ($000) $12,753 Avg Close $11.42 Range $4.17 - $23.85

Q4 2024

Shares 2,202,514 Value ($000) $50,438 Avg Close $23.65 Range $18.62 - $28.99

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,000,000	$55,760	$23.88	$17.55 - $30.50
Q3 2025	2,202,514	$41,429	$13.12	$10.30 - $18.99
Q2 2025	2,202,514	$23,281	$8.24	$4.66 - $11.36
Q1 2025	2,202,514	$12,753	$11.42	$4.17 - $23.85
Q4 2024	2,202,514	$50,438	$23.65	$18.62 - $28.99