SKYE BIOSCIENCE INC

Ticker: SKYE CUSIP: 83086J200 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 478,928 Value ($000) $359 Avg Close $1.46 Range $0.68 - $4.99

Q3 2025

Shares 478,928 Value ($000) $1,882 Avg Close $3.78 Range $2.96 - $4.75

Q2 2025

Shares 538,434 Value ($000) $2,251 Avg Close $2.07 Range $1.14 - $5.75

Q1 2025

Shares 1,476,353 Value ($000) $2,347 Avg Close $2.73 Range $1.56 - $4.25

Q4 2024

Shares 1,564,628 Value ($000) $4,428 Avg Close $4.18 Range $2.31 - $5.96

Q3 2024

Shares 1,563,522 Value ($000) $6,113 Avg Close $5.61 Range $2.95 - $8.26

Q2 2024

Shares 1,298,312 Value ($000) $10,399 Avg Close $11.84 Range $7.00 - $17.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	478,928	$359	$1.46	$0.68 - $4.99
Q3 2025	478,928	$1,882	$3.78	$2.96 - $4.75
Q2 2025	538,434	$2,251	$2.07	$1.14 - $5.75
Q1 2025	1,476,353	$2,347	$2.73	$1.56 - $4.25
Q4 2024	1,564,628	$4,428	$4.18	$2.31 - $5.96
Q3 2024	1,563,522	$6,113	$5.61	$2.95 - $8.26
Q2 2024	1,298,312	$10,399	$11.84	$7.00 - $17.65