SPERO THERAPEUTICS INC

Ticker: SPRO CUSIP: 84833T103 Class: COM

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,279,522 Value ($000) $2,981 Avg Close $2.32 Range $1.89 - $2.75

Q3 2025

Shares 1,452,765 Value ($000) $2,731 Avg Close $2.20 Range $1.80 - $3.22

Q2 2025

Shares 832,165 Value ($000) $2,413 Avg Close $1.44 Range $0.51 - $3.09

Q1 2025

Shares 970,907 Value ($000) $699 Avg Close $0.84 Range $0.70 - $1.13

Q4 2024

Shares 1,105,591 Value ($000) $1,139 Avg Close $1.19 Range $0.92 - $1.36

Q3 2024

Shares 974,653 Value ($000) $1,306 Avg Close $1.34 Range $1.15 - $1.53

Q2 2024

Shares 975,952 Value ($000) $1,269 Avg Close $1.51 Range $1.25 - $1.81

Q1 2024

Shares 854,460 Value ($000) $1 Avg Close $1.57 Range $1.33 - $1.89

Q4 2023

Shares 547,465 Value ($000) $1 Avg Close $1.19 Range $0.99 - $1.50

Q3 2023

Shares 547,165 Value ($000) $1 Avg Close $1.39 Range $1.18 - $1.66

Q2 2023

Shares 593,431 Value ($000) $1 Avg Close $1.71 Range $1.39 - $2.00

Q1 2023

Shares 410,300 Value ($000) $1 Avg Close $1.67 Range $1.35 - $2.04

Q4 2022

Shares 342,900 Value ($000) $1 Avg Close $1.87 Range $1.46 - $2.28

Q3 2022

Shares 214,700 Value ($000) $429 Avg Close $0.99 Range $0.68 - $3.18

Q2 2022

Shares 939,017 Value ($000) $696 Avg Close $2.91 Range $0.73 - $7.87

Q1 2022

Shares 109,100 Value ($000) $949 Avg Close $10.25 Range $7.51 - $16.30

Q3 2020

Shares 153,203 Value ($000) $1,710 Avg Close $11.83 Range $8.50 - $14.37

Q2 2020

Shares 329,903 Value ($000) $4,464 Avg Close $11.23 Range $6.88 - $14.48

Q1 2020

Shares 324,303 Value ($000) $2,620 Avg Close $8.81 Range $5.25 - $10.84

Q4 2019

Shares 338,203 Value ($000) $3,252 Avg Close $10.78 Range $8.74 - $12.46

Q3 2019

Shares 252,803 Value ($000) $2,680 Avg Close $10.54 Range $8.86 - $12.65

Q2 2019

Shares 214,903 Value ($000) $2,474 Avg Close $12.04 Range $9.91 - $14.48

Q1 2019

Shares 113,303 Value ($000) $1,451 Avg Close $10.61 Range $6.00 - $13.50

Q4 2018

Shares 42,903 Value ($000) $264 Avg Close $8.10 Range $5.52 - $11.40

Q3 2018

Shares 12,000 Value ($000) $126 Avg Close $11.61 Range $9.29 - $18.23

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,279,522	$2,981	$2.32	$1.89 - $2.75
Q3 2025	1,452,765	$2,731	$2.20	$1.80 - $3.22
Q2 2025	832,165	$2,413	$1.44	$0.51 - $3.09
Q1 2025	970,907	$699	$0.84	$0.70 - $1.13
Q4 2024	1,105,591	$1,139	$1.19	$0.92 - $1.36
Q3 2024	974,653	$1,306	$1.34	$1.15 - $1.53
Q2 2024	975,952	$1,269	$1.51	$1.25 - $1.81
Q1 2024	854,460	$1	$1.57	$1.33 - $1.89
Q4 2023	547,465	$1	$1.19	$0.99 - $1.50
Q3 2023	547,165	$1	$1.39	$1.18 - $1.66
Q2 2023	593,431	$1	$1.71	$1.39 - $2.00
Q1 2023	410,300	$1	$1.67	$1.35 - $2.04
Q4 2022	342,900	$1	$1.87	$1.46 - $2.28
Q3 2022	214,700	$429	$0.99	$0.68 - $3.18
Q2 2022	939,017	$696	$2.91	$0.73 - $7.87
Q1 2022	109,100	$949	$10.25	$7.51 - $16.30
Q3 2020	153,203	$1,710	$11.83	$8.50 - $14.37
Q2 2020	329,903	$4,464	$11.23	$6.88 - $14.48
Q1 2020	324,303	$2,620	$8.81	$5.25 - $10.84
Q4 2019	338,203	$3,252	$10.78	$8.74 - $12.46
Q3 2019	252,803	$2,680	$10.54	$8.86 - $12.65
Q2 2019	214,903	$2,474	$12.04	$9.91 - $14.48
Q1 2019	113,303	$1,451	$10.61	$6.00 - $13.50
Q4 2018	42,903	$264	$8.10	$5.52 - $11.40
Q3 2018	12,000	$126	$11.61	$9.29 - $18.23