SPERO THERAPEUTICS INC

Ticker: SPRO CUSIP: 84833T103 Class: COM

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019

Shares 131,653 Value ($000) $1,266 Avg Close $10.78 Range $8.74 - $12.46

Q3 2019

Shares 140,709 Value ($000) $1,492 Avg Close $10.54 Range $8.86 - $12.65

Q2 2019

Shares 507,471 Value ($000) $5,841 Avg Close $12.04 Range $9.91 - $14.48

Q1 2019

Shares 507,471 Value ($000) $6,501 Avg Close $10.61 Range $6.00 - $13.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2019	131,653	$1,266	$10.78	$8.74 - $12.46
Q3 2019	140,709	$1,492	$10.54	$8.86 - $12.65
Q2 2019	507,471	$5,841	$12.04	$9.91 - $14.48
Q1 2019	507,471	$6,501	$10.61	$6.00 - $13.50