SPRUCE BIOSCIENCES INC

Ticker: SPRB CUSIP: 85209E208 Class: COM NEW

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
Ikarian Capital, LLC121,356$10,571
Squadron Capital Management LLC70,000$6,098
CITADEL ADVISORS LLC69,999$6,098
WELLINGTON MANAGEMENT GROUP LLP58,949$5,135
ADAR1 Capital Management, LLC58,000$5,052
Alyeska Investment Group, L.P.51,671$4,501
BOOTHBAY FUND MANAGEMENT, LLC47,933$4,175
BALYASNY ASSET MANAGEMENT L.P.40,000$3,484
Carlyle Group Inc.38,620$3,299
ExodusPoint Capital Management, LP25,271$2,201
Schonfeld Strategic Advisors LLC24,767$2,157
Quinn Opportunity Partners LLC22,810$1,987
Caligan Partners LP20,514$1,787
Stonepine Capital Management, LLC19,742$1,720
VANGUARD GROUP INC17,873$1,557
BlackRock, Inc.16,938$1,475
GEODE CAPITAL MANAGEMENT, LLC12,732$1,109
SUPERSTRING CAPITAL MANAGEMENT LP12,137$1,057
STATE STREET CORP6,400$558
UBS Group AG4,902$427
Resolute Capital Asset Partners LLC4,000$348
SkyView Investment Advisors, LLC3,000$0
NORTHERN TRUST CORP2,422$211
BNP PARIBAS ARBITRAGE, SA2,000$174
Lion Point Capital, LP1,000$87
MORGAN STANLEY388$34
Sound Income Strategies, LLC200$15
BANK OF AMERICA CORP /DE/93$8
JONES FINANCIAL COMPANIES LLLP84$7
ROYAL BANK OF CANADA40$3
CALDWELL SUTTER CAPITAL, INC.13$1
Tower Research Capital LLC (TRC)1$0
Total (32 institutions)753,855$65,339