SPRUCE BIOSCIENCES INC

Ticker: SPRB CUSIP: 85209E208 Class: COM NEW

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (24)

Stonepine Capital Management, LLC
Value ($000) $1,720 Shares 19,742
SUPERSTRING CAPITAL MANAGEMENT LP
Value ($000) $1,057 Shares 12,137
ADAR1 Capital Management, LLC
Value ($000) $5,052 Shares 58,000
Caligan Partners LP
Value ($000) $1,787 Shares 20,514
Resolute Capital Asset Partners LLC
Value ($000) $348 Shares 4,000
Quinn Opportunity Partners LLC
Value ($000) $1,987 Shares 22,810
BOOTHBAY FUND MANAGEMENT, LLC
Value ($000) $4,175 Shares 47,933
ExodusPoint Capital Management, LP
Value ($000) $2,201 Shares 25,271
Alyeska Investment Group, L.P.
Value ($000) $4,501 Shares 51,671
Schonfeld Strategic Advisors LLC
Value ($000) $2,157 Shares 24,767
BALYASNY ASSET MANAGEMENT L.P.
Value ($000) $3,484 Shares 40,000
SkyView Investment Advisors, LLC
Value ($000) $0 Shares 3,000
CITADEL ADVISORS LLC
Value ($000) $6,098 Shares 69,999
WELLINGTON MANAGEMENT GROUP LLP
Value ($000) $5,135 Shares 58,949
VANGUARD GROUP INC
Value ($000) $1,557 Shares 17,873
BlackRock, Inc.
Value ($000) $1,475 Shares 16,938
GEODE CAPITAL MANAGEMENT, LLC
Value ($000) $1,109 Shares 12,732
STATE STREET CORP
Value ($000) $558 Shares 6,400
NORTHERN TRUST CORP
Value ($000) $211 Shares 2,422
BNP PARIBAS ARBITRAGE, SA
Value ($000) $174 Shares 2,000

Increased Positions (4)

Ikarian Capital, LLC
Value ($000) $10,571 (+8759.5%) Shares 121,356 (+810.3%)
UBS Group AG
Value ($000) $427 (+36056.9%) Shares 4,902 (+3613.6%)
MORGAN STANLEY
Value ($000) $34 (+3749.5%) Shares 388 (+295.9%)
BANK OF AMERICA CORP /DE/
Value ($000) $8 (+29903.7%) Shares 93 (+3000.0%)

Decreased Positions (1)

Carlyle Group Inc.
Value ($000) $3,299 (-86.7%) Shares 38,620 (-98.7%)

Exited Positions (2)

Cable Car Capital, LP
Value ($000) $239 Shares 26,666
OSAIC HOLDINGS, INC.
Value ($000) $1 Shares 133