STOKE THERAPEUTICS INC

Ticker: STOK CUSIP: 86150R107 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 695,000 Value ($000) $22,059 Avg Close $30.06 Range $20.32 - $38.69

Q3 2025

Shares 682,017 Value ($000) $16,027 Avg Close $17.13 Range $11.19 - $24.97

Q2 2025

Shares 562,120 Value ($000) $6,380 Avg Close $9.49 Range $5.35 - $12.25

Q1 2025

Shares 300,000 Value ($000) $1,995 Avg Close $9.32 Range $6.60 - $12.98

Q4 2024

Shares 25,000 Value ($000) $276 Avg Close $12.29 Range $10.53 - $14.72

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	695,000	$22,059	$30.06	$20.32 - $38.69
Q3 2025	682,017	$16,027	$17.13	$11.19 - $24.97
Q2 2025	562,120	$6,380	$9.49	$5.35 - $12.25
Q1 2025	300,000	$1,995	$9.32	$6.60 - $12.98
Q4 2024	25,000	$276	$12.29	$10.53 - $14.72