| FMR LLC | 5,600,920 | $177,773 |
| RTW INVESTMENTS, LP | 5,546,856 | $176,057 |
| Lynx1 Capital Management LP | 5,404,674 | $171,544 |
| BlackRock, Inc. | 5,212,554 | $165,446 |
| Redmile Group, LLC | 4,034,070 | $128,041 |
| MORGAN STANLEY | 3,546,158 | $112,555 |
| BAKER BROS. ADVISORS LP | 3,336,697 | $105,907 |
| TORONTO DOMINION BANK | 3,173,258 | $100,719 |
| VANGUARD GROUP INC | 3,149,239 | $99,957 |
| STATE STREET CORP | 2,498,049 | $79,288 |
| BVF INC/IL | 2,265,674 | $71,912 |
| Siren, L.L.C. | 2,247,347 | $71,331 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,823,500 | $57,878 |
| JANUS HENDERSON GROUP PLC | 1,450,933 | $46,031 |
| Polar Capital Holdings Plc | 1,269,131 | $40,282 |
| Assenagon Asset Management S.A. | 1,227,723 | $38,968 |
| Point72 Asset Management, L.P. | 1,222,213 | $38,793 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,166,145 | $37,020 |
| GOLDMAN SACHS GROUP INC | 1,142,737 | $36,270 |
| DIMENSIONAL FUND ADVISORS LP | 827,139 | $26,254 |
| MPM BioImpact LLC | 770,289 | $24,449 |
| WELLINGTON MANAGEMENT GROUP LLP | 735,799 | $23,354 |
| Opaleye Management Inc. | 695,000 | $22,059 |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | $15,870 |
| Candriam S.C.A. | 446,690 | $14,179 |
| Parkman Healthcare Partners LLC | 430,155 | $13,653 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,906 | $13,042 |
| NORTHERN TRUST CORP | 403,168 | $12,797 |
| Erste Asset Management GmbH | 396,000 | $12,598 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 372,334 | $12 |
| JPMORGAN CHASE & CO | 277,930 | $8,821 |
| Birchview Capital, LP | 260,000 | $8,252 |
| Invesco Ltd. | 259,543 | $8,238 |
| BAILLIE GIFFORD & CO | 246,900 | $7,837 |
| Rhenman & Partners Asset Management AB | 216,000 | $6,856 |
| BANK OF AMERICA CORP /DE/ | 206,164 | $6,544 |
| Granahan Investment Management, LLC | 191,397 | $6,075 |
| UBS Group AG | 169,713 | $5,387 |
| FIRST TRUST ADVISORS LP | 162,679 | $5,163 |
| BARCLAYS PLC | 150,945 | $4,791 |
| Bank of New York Mellon Corp | 140,802 | $4,469 |
| FRANKLIN RESOURCES INC | 132,222 | $4,197 |
| Susquehanna Portfolio Strategies, LLC | 126,350 | $4,010 |
| GILDER GAGNON HOWE & CO LLC | 122,448 | $3,887 |
| EAM Investors, LLC | 117,823 | $3,740 |
| HighVista Strategies LLC | 115,539 | $3,667 |
| AMERICAN CENTURY COMPANIES INC | 115,118 | $3,654 |
| DAFNA Capital Management LLC | 108,875 | $3,456 |
| Nuveen, LLC | 104,261 | $3,309 |
| Rafferty Asset Management, LLC | 90,193 | $2,863 |
| Penserra Capital Management LLC | 88,507 | $3 |
| Quantedge Capital Pte Ltd | 87,200 | $2,768 |
| Swiss National Bank | 75,700 | $2,403 |
| Alyeska Investment Group, L.P. | 75,000 | $2,381 |
| Palo Alto Investors LP | 72,022 | $2,286 |
| PRINCIPAL FINANCIAL GROUP INC | 70,282 | $2,231 |
| JANE STREET GROUP, LLC | 67,112 | $2,130 |
| ALPS ADVISORS INC | 66,502 | $2,111 |
| Schonfeld Strategic Advisors LLC | 63,109 | $2,003 |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63,000 | $2,000 |
| RHUMBLINE ADVISERS | 62,414 | $1,981 |
| UBS ASSET MANAGEMENT AMERICAS INC | 57,212 | $1,816 |
| Privium Fund Management B.V. | 55,000 | $1,746 |
| Woodline Partners LP | 50,120 | $1,591 |
| D. E. Shaw & Co., Inc. | 49,901 | $1,584 |
| WELLS FARGO & COMPANY/MN | 49,585 | $1,574 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,022 | $1,461 |
| NOMURA HOLDINGS INC | 44,352 | $1,408 |
| Creative Planning | 41,712 | $1,324 |
| VICTORY CAPITAL MANAGEMENT INC | 41,140 | $1,306 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 40,815 | $1,295 |
| ALLIANCEBERNSTEIN L.P. | 40,630 | $1,290 |
| Kennondale Capital Management LLC | 38,731 | $1,229 |
| Harvest Investment Services, LLC | 38,347 | $1,217 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,127 | $1,178 |
| Legal & General Group Plc | 36,366 | $1,154 |
| CANADA PENSION PLAN INVESTMENT BOARD | 35,200 | $1,117 |
| DEUTSCHE BANK AG\ | 33,406 | $1,060 |
| PROFUND ADVISORS LLC | 33,388 | $1,060 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,515 | $1,032 |
| AQR CAPITAL MANAGEMENT LLC | 29,467 | $935 |
| READYSTATE ASSET MANAGEMENT LP | 29,059 | $922 |
| Cresset Asset Management, LLC | 26,325 | $836 |
| SG Americas Securities, LLC | 25,836 | $1 |
| MetLife Investment Management, LLC | 25,320 | $804 |
| Allspring Global Investments Holdings, LLC | 24,462 | $756 |
| AMERIPRISE FINANCIAL INC | 21,076 | $669 |
| TUDOR INVESTMENT CORP ET AL | 19,309 | $613 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 19,101 | $606 |
| INTECH INVESTMENT MANAGEMENT LLC | 18,652 | $592 |
| DIADEMA PARTNERS LP | 17,181 | $545 |
| SEI INVESTMENTS CO | 16,631 | $528 |
| PSP Research LLC | 16,621 | $528 |
| AVIVA PLC | 15,871 | $504 |
| CITADEL ADVISORS LLC | 15,851 | $503 |
| AlphaQuest LLC | 15,036 | $477 |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,035 | $477 |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,819 | $470 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 14,768 | $0 |
| SIMPLEX TRADING, LLC | 14,281 | $453 |
| 81 other institutions | 371,587 | $10,693 |