SYNLOGIC INC

Ticker: SYBX CUSIP: 87166L209 Class: COM NEW

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (5)

DRW Securities, LLC

Value ($000) $27 Shares 24,363

JANE STREET GROUP, LLC

Value ($000) $17 Shares 14,998

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $13 Shares 11,623

Value ($000) $3 Shares 2,531

FLAGSHIP HARBOR ADVISORS, LLC

Value ($000) $1 Shares 1,033

Institution	Shares	Value ($000)
DRW Securities, LLC	24,363	$27
JANE STREET GROUP, LLC	14,998	$17
SUSQUEHANNA INTERNATIONAL GROUP, LLP	11,623	$13
UBS Group AG	2,531	$3
FLAGSHIP HARBOR ADVISORS, LLC	1,033	$1

Increased Positions (6)

CITADEL ADVISORS LLC

Value ($000) $159 (+223.5%) Shares 141,608 (+388.1%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $96 (+45.5%) Shares 85,627 (+116.7%)

VANGUARD GROUP INC

Value ($000) $225 (-32.2%) Shares 201,060 (+2.3%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $80 (-29.8%) Shares 71,645 (+5.9%)

Value ($000) $16 (-14.6%) Shares 14,398 (+28.9%)

BANK OF AMERICA CORP /DE/

Value ($000) $0 (-31.8%) Shares 66 (+3.1%)

Institution	Prev Shares	Curr Shares	Change
CITADEL ADVISORS LLC	29,011	141,608	+112,597 (+388.1%)
RENAISSANCE TECHNOLOGIES LLC	39,510	85,627	+46,117 (+116.7%)
VANGUARD GROUP INC	196,461	201,060	+4,599 (+2.3%)
GEODE CAPITAL MANAGEMENT, LLC	67,665	71,645	+3,980 (+5.9%)
XTX Topco Ltd	11,173	14,398	+3,225 (+28.9%)
BANK OF AMERICA CORP /DE/	64	66	+2 (+3.1%)

Decreased Positions (1)

Ikarian Capital, LLC

Value ($000) $22 (-35.2%) Shares 19,966 (-2.2%)

Institution	Prev Shares	Curr Shares	Change
Ikarian Capital, LLC	20,422	19,966	-456 (-2.2%)

Exited Positions (2)

JONES FINANCIAL COMPANIES LLLP

Value ($000) $0 Shares 20

WELLS FARGO & COMPANY/MN

Value ($000) $0 Shares 5

Institution	Prev Shares	Prev Value ($000)
JONES FINANCIAL COMPANIES LLLP	20	$0
WELLS FARGO & COMPANY/MN	5	$0