| FARALLON CAPITAL MANAGEMENT LLC | 13,061,411 | $115,724 |
| TCG Crossover Management, LLC | 12,762,094 | $113,072 |
| Boxer Capital Management, LLC | 10,876,219 | $96,363 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10,607,924 | $93,986 |
| Woodline Partners LP | 10,072,225 | $89,240 |
| BlackRock, Inc. | 8,540,797 | $75,671 |
| Siren, L.L.C. | 8,165,374 | $72,345 |
| TRV GP IV, LLC | 7,874,574 | $69,769 |
| Nextech Invest, Ltd. | 7,266,081 | $64,377 |
| VANGUARD GROUP INC | 6,750,977 | $59,814 |
| STATE STREET CORP | 6,218,567 | $55,097 |
| BALYASNY ASSET MANAGEMENT L.P. | 5,278,580 | $46,768 |
| GOLDMAN SACHS GROUP INC | 4,942,414 | $43,790 |
| Logos Global Management LP | 4,200,000 | $37,212 |
| Bellevue Group AG | 3,927,670 | $34,799 |
| Caligan Partners LP | 3,729,895 | $33,047 |
| Nantahala Capital Management, LLC | 3,572,633 | $31,654 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,906,946 | $25,756 |
| FMR LLC | 2,867,548 | $25,406 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,662,227 | $23,587 |
| JANUS HENDERSON GROUP PLC | 2,644,237 | $23,468 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,553,656 | $22,630 |
| Deep Track Capital, LP | 2,454,562 | $21,747 |
| Vivo Capital, LLC | 2,154,780 | $19,091 |
| Point72 Asset Management, L.P. | 1,974,035 | $17,490 |
| RTW INVESTMENTS, LP | 1,491,228 | $13,212 |
| MORGAN STANLEY | 1,421,794 | $12,597 |
| FRANKLIN RESOURCES INC | 1,398,057 | $12,387 |
| D. E. Shaw & Co., Inc. | 1,025,553 | $9,086 |
| Affinity Asset Advisors, LLC | 1,000,000 | $8,860 |
| UBS Group AG | 990,458 | $8,775 |
| BOOTHBAY FUND MANAGEMENT, LLC | 957,282 | $8,482 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 840,992 | $7,451 |
| NORTHERN TRUST CORP | 803,199 | $7,116 |
| Candriam S.C.A. | 708,812 | $6,280 |
| BESSEMER GROUP INC | 708,398 | $6 |
| ArrowMark Colorado Holdings LLC | 708,385 | $6,276 |
| Bain Capital Life Sciences Investors, LLC | 653,493 | $5,790 |
| MILLENNIUM MANAGEMENT LLC | 593,004 | $5,254 |
| SPHERA FUNDS MANAGEMENT LTD. | 544,563 | $4,825 |
| PERCEPTIVE ADVISORS LLC | 513,035 | $4,545 |
| DIMENSIONAL FUND ADVISORS LP | 487,076 | $4,315 |
| BANK OF AMERICA CORP /DE/ | 478,062 | $4,236 |
| T. Rowe Price Investment Management, Inc. | 399,611 | $4 |
| Rock Springs Capital Management LP | 386,915 | $3,428 |
| BARCLAYS PLC | 368,187 | $3,262 |
| Mass General Brigham, Inc | 354,192 | $3,138 |
| Bank of New York Mellon Corp | 343,840 | $3,046 |
| MARSHALL WACE, LLP | 329,231 | $2,917 |
| Qube Research & Technologies Ltd | 318,676 | $2,823 |
| Nuveen, LLC | 300,441 | $2,662 |
| GREAT LAKES ADVISORS, LLC | 294,303 | $2,608 |
| ACUTA CAPITAL PARTNERS, LLC | 282,732 | $2,505 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 255,127 | $2,260 |
| CONGRESS ASSET MANAGEMENT CO /MA | 234,628 | $2,079 |
| WELLINGTON MANAGEMENT GROUP LLP | 233,857 | $2,072 |
| Rafferty Asset Management, LLC | 226,601 | $2,008 |
| Seven Fleet Capital Management LP | 215,172 | $1,906 |
| Integral Health Asset Management, LLC | 200,000 | $1,772 |
| TRV GP VI, LLC | 194,174 | $1,720 |
| Fisher Asset Management, LLC | 187,693 | $1,663 |
| Invesco Ltd. | 177,610 | $1,574 |
| Squarepoint Ops LLC | 173,936 | $1,541 |
| CITADEL ADVISORS LLC | 151,880 | $1,346 |
| TWO SIGMA INVESTMENTS, LP | 144,432 | $1,280 |
| ADAR1 Capital Management, LLC | 140,021 | $1,241 |
| Connor, Clark & Lunn Investment Management Ltd. | 129,476 | $1,147 |
| RHUMBLINE ADVISERS | 129,107 | $1,144 |
| Verition Fund Management LLC | 121,781 | $1,079 |
| WELLS FARGO & COMPANY/MN | 121,186 | $1,074 |
| GSA CAPITAL PARTNERS LLP | 118,593 | $1 |
| ALLIANCEBERNSTEIN L.P. | 106,490 | $944 |
| Trexquant Investment LP | 105,268 | $933 |
| Swiss National Bank | 87,800 | $778 |
| PROFUND ADVISORS LLC | 83,759 | $742 |
| AQR CAPITAL MANAGEMENT LLC | 82,233 | $729 |
| DEUTSCHE BANK AG\ | 74,203 | $657 |
| TUDOR INVESTMENT CORP ET AL | 68,251 | $605 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 64,243 | $512 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 62,634 | $552 |
| DekaBank Deutsche Girozentrale | 60,000 | $1 |
| MetLife Investment Management, LLC | 59,692 | $529 |
| Y-Intercept (Hong Kong) Ltd | 59,330 | $526 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,434 | $1 |
| JPMORGAN CHASE & CO | 56,835 | $504 |
| SEI INVESTMENTS CO | 53,927 | $478 |
| Graham Capital Management, L.P. | 51,319 | $455 |
| CANADA PENSION PLAN INVESTMENT BOARD | 50,400 | $447 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,210 | $427 |
| Voya Investment Management LLC | 47,811 | $424 |
| SmartHarvest Portfolios, LLC | 46,123 | $409 |
| Creative Planning | 41,907 | $371 |
| UBS ASSET MANAGEMENT AMERICAS INC | 41,453 | $367 |
| Legal & General Group Plc | 39,430 | $349 |
| INTECH INVESTMENT MANAGEMENT LLC | 38,941 | $345 |
| XTX Topco Ltd | 37,838 | $335 |
| CITIGROUP INC | 36,236 | $321 |
| Janney Montgomery Scott LLC | 36,000 | $0 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,216 | $312 |
| Philadelphia Financial Management of San Francisco, LLC | 33,291 | $295 |
| 69 other institutions | 754,312 | $6,404 |