TREVI THERAPEUTICS INC

Ticker: TRVI CUSIP: 89532M101 Class: Common Stock

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,190,700 Value ($000) $39,948 Avg Close $11.56 Range $8.99 - $14.39

Q3 2025

Shares 3,308,400 Value ($000) $30,272 Avg Close $7.50 Range $5.47 - $9.92

Q2 2025

Shares 3,308,400 Value ($000) $18,097 Avg Close $6.22 Range $4.85 - $7.48

Q1 2025

Shares 1,120,000 Value ($000) $7,045 Avg Close $4.77 Range $3.47 - $7.39

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,190,700	$39,948	$11.56	$8.99 - $14.39
Q3 2025	3,308,400	$30,272	$7.50	$5.47 - $9.92
Q2 2025	3,308,400	$18,097	$6.22	$4.85 - $7.48
Q1 2025	1,120,000	$7,045	$4.77	$3.47 - $7.39