| NEA Management Company, LLC | 13,222,228 | $165,542 |
| Frazier Life Sciences Management, L.P. | 10,259,409 | $128,448 |
| BlackRock, Inc. | 10,126,183 | $126,780 |
| FMR LLC | 6,500,009 | $81,380 |
| VANGUARD GROUP INC | 6,434,655 | $80,562 |
| Vivo Capital, LLC | 5,094,668 | $63,785 |
| MARSHALL WACE, LLP | 4,580,548 | $57,348 |
| Rubric Capital Management LP | 3,766,749 | $47,160 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,403,990 | $42,618 |
| MPM BioImpact LLC | 3,287,087 | $41,154 |
| VIKING GLOBAL INVESTORS LP | 3,198,644 | $40,047 |
| ORBIMED ADVISORS LLC | 3,190,700 | $39,948 |
| ALLIANCEBERNSTEIN L.P. | 3,082,986 | $38,599 |
| Octagon Capital Advisors LP | 2,815,000 | $35,244 |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,622,306 | $32,831 |
| STATE STREET CORP | 2,435,000 | $30,486 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,412,885 | $30,214 |
| Siren, L.L.C. | 2,286,867 | $28,632 |
| Affinity Asset Advisors, LLC | 2,150,172 | $26,920 |
| ACORN CAPITAL ADVISORS, LLC | 2,144,844 | $26,853 |
| Artia Global Partners LP | 2,013,602 | $25,210 |
| EMERALD ADVISERS, LLC | 1,892,276 | $23,691 |
| RAYMOND JAMES FINANCIAL INC | 1,766,963 | $22,122 |
| Logos Global Management LP | 1,550,000 | $19,406 |
| Pictet Asset Management Holding SA | 1,532,013 | $19,181 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,272,373 | $15,930 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,256,782 | $15,735 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,108,468 | $13,878 |
| BANK OF AMERICA CORP /DE/ | 1,094,851 | $13,708 |
| GOLDMAN SACHS GROUP INC | 1,056,891 | $13,232 |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1,053,427 | $13,189 |
| MORGAN STANLEY | 1,050,296 | $13,150 |
| Woodline Partners LP | 1,000,282 | $12,524 |
| Point72 Asset Management, L.P. | 1,000,000 | $12,520 |
| NAN FUNG TRINITY (HK) LTD | 917,450 | $11,486 |
| Soleus Capital Management, L.P. | 900,000 | $11,268 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 836,800 | $10,477 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 825,548 | $10,336 |
| NORTHERN TRUST CORP | 761,966 | $9,540 |
| PANAGORA ASSET MANAGEMENT INC | 693,001 | $8,676 |
| SPHERA FUNDS MANAGEMENT LTD. | 598,534 | $7,494 |
| BARCLAYS PLC | 582,653 | $7,295 |
| MILLENNIUM MANAGEMENT LLC | 570,226 | $7,139 |
| PRUDENTIAL FINANCIAL INC | 549,219 | $6,876 |
| EAM Investors, LLC | 541,242 | $6,776 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 541,240 | $6,776 |
| Burkehill Global Management, LP | 525,000 | $6,573 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 507,685 | $6,356 |
| Invesco Ltd. | 498,926 | $6,247 |
| J. Goldman & Co LP | 444,357 | $5,563 |
| KVP Capital Advisors, LP | 414,000 | $5,183 |
| STEMPOINT CAPITAL LP | 399,557 | $5,002 |
| Opaleye Management Inc. | 345,100 | $4,321 |
| AMERIPRISE FINANCIAL INC | 324,172 | $4,059 |
| UBS Group AG | 274,628 | $3,438 |
| Bank of New York Mellon Corp | 260,587 | $3,263 |
| F/M Investments LLC | 241,483 | $3,023 |
| Voya Investment Management LLC | 226,215 | $2,832 |
| Velan Capital Investment Management LP | 205,000 | $2,567 |
| Nuveen, LLC | 183,329 | $2,295 |
| BALYASNY ASSET MANAGEMENT L.P. | 174,641 | $2,187 |
| Swiss National Bank | 168,200 | $2,106 |
| FRED ALGER MANAGEMENT, LLC | 157,980 | $1,978 |
| CITADEL ADVISORS LLC | 152,855 | $1,914 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 148,292 | $1,857 |
| SEI INVESTMENTS CO | 147,941 | $1,852 |
| D. E. Shaw & Co., Inc. | 141,312 | $1,769 |
| UBS ASSET MANAGEMENT AMERICAS INC | 140,733 | $1,762 |
| BIT Capital GmbH | 130,000 | $1,628 |
| HRT FINANCIAL LP | 125,104 | $2 |
| SG Americas Securities, LLC | 124,562 | $2 |
| CITIGROUP INC | 123,498 | $1,546 |
| STATE OF WISCONSIN INVESTMENT BOARD | 120,566 | $1,509 |
| HighVista Strategies LLC | 106,159 | $1,329 |
| RHUMBLINE ADVISERS | 105,922 | $1,326 |
| WELLS FARGO & COMPANY/MN | 101,279 | $1,268 |
| OPPENHEIMER & CO INC | 100,698 | $1,261 |
| LMR Partners LLP | 100,000 | $1,252 |
| Rosalind Advisors, Inc. | 100,000 | $1,252 |
| DIADEMA PARTNERS LP | 97,184 | $1,217 |
| Erste Asset Management GmbH | 90,000 | $1,154 |
| SECTORAL ASSET MANAGEMENT INC | 84,255 | $1,055 |
| XTX Topco Ltd | 83,818 | $1,049 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,788 | $1,049 |
| TWO SIGMA INVESTMENTS, LP | 83,755 | $1,049 |
| COMERICA BANK | 83,027 | $1,039 |
| WEXFORD CAPITAL LP | 82,034 | $1,027 |
| Legal & General Group Plc | 81,673 | $1,023 |
| PFS Partners, LLC | 79,000 | $989 |
| MAI Capital Management | 77,769 | $974 |
| Hudson Bay Capital Management LP | 75,000 | $939 |
| Campbell & CO Investment Adviser LLC | 71,097 | $890 |
| DEUTSCHE BANK AG\ | 70,833 | $887 |
| TUDOR INVESTMENT CORP ET AL | 68,481 | $857 |
| WealthTrust Axiom LLC | 61,500 | $770 |
| Optimize Financial Inc | 61,483 | $770 |
| JPMORGAN CHASE & CO | 59,475 | $745 |
| Russell Investments Group, Ltd. | 59,444 | $744 |
| KENNEDY CAPITAL MANAGEMENT LLC | 56,269 | $704 |
| LPL Financial LLC | 52,960 | $663 |
| 82 other institutions | 1,438,376 | $17,297 |