TREVI THERAPEUTICS INC

Ticker: TRVI CUSIP: 89532M101 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 598,534 Value ($000) $7,494 Avg Close $11.56 Range $8.99 - $14.39

Q3 2025

Shares 643,957 Value ($000) $5,892 Avg Close $7.50 Range $5.47 - $9.92

Q2 2025

Shares 799,957 Value ($000) $4,376 Avg Close $6.22 Range $4.85 - $7.48

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	598,534	$7,494	$11.56	$8.99 - $14.39
Q3 2025	643,957	$5,892	$7.50	$5.47 - $9.92
Q2 2025	799,957	$4,376	$6.22	$4.85 - $7.48