ULTRAGENYX PHARMACEUTICAL IN

Ticker: RARE CUSIP: 90400D108 Class: EQTY

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 227,600 Value ($000) $16,528 Avg Close $69.58 Range $61.20 - $88.12

Q3 2019

Shares 834,313 Value ($000) $35,692 Avg Close $54.32 Range $41.35 - $65.00

Q2 2019

Shares 79,607 Value ($000) $5,055 Avg Close $63.65 Range $54.41 - $74.50

Q2 2018

Shares 67,605 Value ($000) $5,197 Avg Close $64.59 Range $48.04 - $86.10

Q4 2016

Shares 169,300 Value ($000) $11,903 Avg Close $70.94 Range $52.60 - $86.77

Q3 2016

Shares 169,300 Value ($000) $12,010 Avg Close $63.83 Range $48.33 - $81.40

Q2 2016

Shares 169,300 Value ($000) $8,280 Avg Close $64.69 Range $46.52 - $78.13

Q1 2016

Shares 128,300 Value ($000) $8,123 Avg Close $65.43 Range $49.00 - $110.06

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	227,600	$16,528	$69.58	$61.20 - $88.12
Q3 2019	834,313	$35,692	$54.32	$41.35 - $65.00
Q2 2019	79,607	$5,055	$63.65	$54.41 - $74.50
Q2 2018	67,605	$5,197	$64.59	$48.04 - $86.10
Q4 2016	169,300	$11,903	$70.94	$52.60 - $86.77
Q3 2016	169,300	$12,010	$63.83	$48.33 - $81.40
Q2 2016	169,300	$8,280	$64.69	$46.52 - $78.13
Q1 2016	128,300	$8,123	$65.43	$49.00 - $110.06