UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

NORTHERN TRUST CORP's Holding History (CIK: 0000073124)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 236,799 Value ($000) $6,429 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 254,719 Value ($000) $4,791 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 229,303 Value ($000) $2,518 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 137,771 Value ($000) $843 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 143,721 Value ($000) $2,363 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	236,799	$6,429	$24.89	$18.05 - $33.00
Q3 2025	254,719	$4,791	$15.54	$10.54 - $21.03
Q2 2025	229,303	$2,518	$9.24	$5.14 - $12.10
Q1 2025	137,771	$843	$9.55	$6.12 - $18.95
Q4 2024	143,721	$2,363	$22.33	$14.97 - $29.46