UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

ROYAL BANK OF CANADA's Holding History (CIK: 0001000275)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 969 Value ($000) $26 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 832 Value ($000) $16 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 3,090 Value ($000) $33 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 832 Value ($000) $5 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 1,282 Value ($000) $21 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	969	$26	$24.89	$18.05 - $33.00
Q3 2025	832	$16	$15.54	$10.54 - $21.03
Q2 2025	3,090	$33	$9.24	$5.14 - $12.10
Q1 2025	832	$5	$9.55	$6.12 - $18.95
Q4 2024	1,282	$21	$22.33	$14.97 - $29.46