UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,400 Value ($000) $445 Avg Close $24.89 Range $18.05 - $33.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,400	$445	$24.89	$18.05 - $33.00