UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

AQR CAPITAL MANAGEMENT LLC's Holding History (CIK: 0001167557)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 30,503 Value ($000) $828 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 29,954 Value ($000) $563 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 29,752 Value ($000) $327 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 18,822 Value ($000) $115 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	30,503	$828	$24.89	$18.05 - $33.00
Q3 2025	29,954	$563	$15.54	$10.54 - $21.03
Q2 2025	29,752	$327	$9.24	$5.14 - $12.10
Q1 2025	18,822	$115	$9.55	$6.12 - $18.95