UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Rafferty Asset Management, LLC's Holding History (CIK: 0001389426)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 38,683 Value ($000) $1,050 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 34,521 Value ($000) $649 Avg Close $15.54 Range $10.54 - $21.03

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	38,683	$1,050	$24.89	$18.05 - $33.00
Q3 2025	34,521	$649	$15.54	$10.54 - $21.03