UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

EcoR1 Capital, LLC's Holding History (CIK: 0001587114)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025

Shares 60,000 Value ($000) $367 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 60,000 Value ($000) $986 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2025	60,000	$367	$9.55	$6.12 - $18.95
Q4 2024	60,000	$986	$22.33	$14.97 - $29.46