UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

OSAIC HOLDINGS, INC.'s Holding History (CIK: 0001677044)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 5 Value ($000) $0 Avg Close $24.89 Range $18.05 - $33.00

Q2 2025

Shares 42 Value ($000) $0 Avg Close $9.24 Range $5.14 - $12.10

Q4 2024

Shares 17 Value ($000) $0 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	5	$0	$24.89	$18.05 - $33.00
Q2 2025	42	$0	$9.24	$5.14 - $12.10
Q4 2024	17	$0	$22.33	$14.97 - $29.46