UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Integral Health Asset Management, LLC's Holding History (CIK: 0001773206)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 750,000 Value ($000) $20,363 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 575,000 Value ($000) $10,816 Avg Close $15.54 Range $10.54 - $21.03

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	750,000	$20,363	$24.89	$18.05 - $33.00
Q3 2025	575,000	$10,816	$15.54	$10.54 - $21.03