UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Siren, L.L.C.'s Holding History (CIK: 0002005245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 588,450 Value ($000) $15,976 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 788,450 Value ($000) $14,831 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 788,450 Value ($000) $8,657 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 788,450 Value ($000) $4,825 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 800,000 Value ($000) $13,152 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	588,450	$15,976	$24.89	$18.05 - $33.00
Q3 2025	788,450	$14,831	$15.54	$10.54 - $21.03
Q2 2025	788,450	$8,657	$9.24	$5.14 - $12.10
Q1 2025	788,450	$4,825	$9.55	$6.12 - $18.95
Q4 2024	800,000	$13,152	$22.33	$14.97 - $29.46