VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

STATE OF MICHIGAN RETIREMENT SYSTEM's Holding History (CIK: 0000762152)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 69,223 Value ($000) $31,383 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 72,023 Value ($000) $28,207 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 72,523 Value ($000) $32,287 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 72,123 Value ($000) $34,967 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 72,423 Value ($000) $29,165 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 73,623 Value ($000) $34,241 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 73,923 Value ($000) $34,649 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 73,123 Value ($000) $30,566 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 73,023 Value ($000) $29,712 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 72,923 Value ($000) $25,358 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 73,523 Value ($000) $25,873 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 73,823 Value ($000) $23,259 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 72,923 Value ($000) $21,059 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 73,423 Value ($000) $21,259 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 73,023 Value ($000) $20,577 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 64,223 Value ($000) $16,760 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 64,034 Value ($000) $14,062 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 65,134 Value ($000) $11,815 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 65,034 Value ($000) $13,113 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 65,234 Value ($000) $14,018 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 65,434 Value ($000) $15,465 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 183,934 Value ($000) $50,052 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 163,434 Value ($000) $47,447 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 142,968 Value ($000) $34,019 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 146,168 Value ($000) $32,003 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 145,768 Value ($000) $24,696 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 89,268 Value ($000) $16,370 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 141,668 Value ($000) $26,060 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 133,168 Value ($000) $22,067 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 76,168 Value ($000) $14,681 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 75,468 Value ($000) $12,827 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 74,768 Value ($000) $12,186 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 74,168 Value ($000) $11,115 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 76,468 Value ($000) $11,626 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 81,868 Value ($000) $10,550 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 81,568 Value ($000) $8,919 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 81,068 Value ($000) $5,972 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 86,500 Value ($000) $7,544 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 85,900 Value ($000) $7,389 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 84,800 Value ($000) $6,741 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 84,000 Value ($000) $10,570 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 88,300 Value ($000) $9,196 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 94,500 Value ($000) $11,669 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 93,400 Value ($000) $11,018 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 99,100 Value ($000) $11,773 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 97,600 Value ($000) $10,961 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 96,800 Value ($000) $9,165 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 96,200 Value ($000) $6,803 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 95,000 Value ($000) $7,058 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 94,700 Value ($000) $7,180 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 101,900 Value ($000) $8,139 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	69,223	$31,383	$431.03	$392.50 - $464.44
Q3 2025	72,023	$28,207	$417.92	$362.50 - $484.56
Q2 2025	72,523	$32,287	$460.83	$416.60 - $510.77
Q1 2025	72,123	$34,967	$466.00	$397.25 - $519.68
Q4 2024	72,423	$29,165	$463.53	$377.85 - $519.88
Q3 2024	73,623	$34,241	$480.37	$456.07 - $510.64
Q2 2024	73,923	$34,649	$434.05	$391.01 - $486.43
Q1 2024	73,123	$30,566	$422.74	$403.43 - $448.40
Q4 2023	73,023	$29,712	$369.42	$341.85 - $413.00
Q3 2023	72,923	$25,358	$349.73	$335.82 - $367.00
Q2 2023	73,523	$25,873	$336.94	$313.47 - $354.94
Q1 2023	73,823	$23,259	$299.93	$282.21 - $325.19
Q4 2022	72,923	$21,059	$304.77	$283.58 - $324.75
Q3 2022	73,423	$21,259	$287.72	$271.61 - $305.95
Q2 2022	73,023	$20,577	$267.66	$233.01 - $293.17
Q1 2022	64,223	$16,760	$237.33	$214.66 - $263.58
Q4 2021	64,034	$14,062	$194.45	$176.36 - $224.49
Q3 2021	65,134	$11,815	$195.24	$180.02 - $204.88
Q2 2021	65,034	$13,113	$209.17	$185.33 - $222.78
Q1 2021	65,234	$14,018	$219.65	$204.62 - $242.99
Q4 2020	65,434	$15,465	$229.44	$202.57 - $280.99
Q3 2020	183,934	$50,052	$275.88	$253.97 - $306.08
Q2 2020	163,434	$47,447	$271.12	$222.39 - $299.21
Q1 2020	142,968	$34,019	$229.39	$197.47 - $249.85
Q4 2019	146,168	$32,003	$202.38	$165.23 - $225.66
Q3 2019	145,768	$24,696	$176.91	$165.27 - $188.44
Q2 2019	89,268	$16,370	$174.82	$163.68 - $191.71
Q1 2019	141,668	$26,060	$184.70	$160.95 - $195.81
Q4 2018	133,168	$22,067	$173.27	$151.80 - $194.92
Q3 2018	76,168	$14,681	$178.07	$164.70 - $193.78
Q2 2018	75,468	$12,827	$155.01	$144.07 - $172.00
Q1 2018	74,768	$12,186	$163.34	$146.21 - $178.15
Q4 2017	74,168	$11,115	$148.07	$136.50 - $158.04
Q3 2017	76,468	$11,626	$150.51	$125.50 - $167.86
Q2 2017	81,868	$10,550	$120.38	$107.24 - $137.26
Q1 2017	81,568	$8,919	$88.04	$73.34 - $111.88
Q4 2016	81,068	$5,972	$81.37	$71.46 - $97.93
Q3 2016	86,500	$7,544	$94.50	$83.50 - $103.73
Q2 2016	85,900	$7,389	$86.41	$75.92 - $96.49
Q1 2016	84,800	$6,741	$90.45	$75.90 - $124.96
Q4 2015	84,000	$10,570	$120.72	$101.49 - $134.71
Q3 2015	88,300	$9,196	$128.47	$97.45 - $143.45
Q2 2015	94,500	$11,669	$125.98	$113.68 - $137.50
Q1 2015	93,400	$11,018	$119.81	$103.75 - $136.33
Q4 2014	99,100	$11,773	$112.63	$96.43 - $124.35
Q3 2014	97,600	$10,961	$95.21	$84.41 - $116.88
Q2 2014	96,800	$9,165	$70.12	$59.79 - $98.80
Q1 2014	96,200	$6,803	$79.20	$67.49 - $87.77
Q4 2013	95,000	$7,058	$69.64	$58.06 - $78.38
Q3 2013	94,700	$7,180	$79.58	$73.43 - $89.96
Q2 2013	101,900	$8,139	$73.64	$51.28 - $87.47