VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 210,287 Value ($000) $93,620 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 159,900 Value ($000) $77,523 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 151,000 Value ($000) $60,808 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 151,000 Value ($000) $70,227 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 151,000 Value ($000) $70,777 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 122,700 Value ($000) $51,290 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 175,200 Value ($000) $71,287 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 165,400 Value ($000) $57,516 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 165,400 Value ($000) $58,206 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 177,600 Value ($000) $55,956 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 271,500 Value ($000) $78,404 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 373,200 Value ($000) $108,056 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 387,200 Value ($000) $109,109 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 400,200 Value ($000) $104,440 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 658,100 Value ($000) $144,519 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 877,400 Value ($000) $159,152 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,065,400 Value ($000) $214,817 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,135,900 Value ($000) $244,094 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 834,100 Value ($000) $197,131 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 666,100 Value ($000) $181,259 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 666,100 Value ($000) $193,375 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 737,400 Value ($000) $175,464 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 783,100 Value ($000) $171,460 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 846,400 Value ($000) $143,397 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 973,300 Value ($000) $178,484 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 955,300 Value ($000) $175,727 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,133,200 Value ($000) $187,783 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,600,500 Value ($000) $308,480 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,792,600 Value ($000) $304,670 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 1,854,600 Value ($000) $302,263 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,741,300 Value ($000) $260,951 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 2,074,302 Value ($000) $315,377 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 2,026,502 Value ($000) $261,155 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 2,169,200 Value ($000) $237,202 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 2,159,400 Value ($000) $159,083 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 1,612,000 Value ($000) $140,583 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 2,189,300 Value ($000) $188,324 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,869,400 Value ($000) $148,599 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 673,000 Value ($000) $84,684 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 115,000 Value ($000) $11,976 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 115,000 Value ($000) $14,200 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 135,000 Value ($000) $15,926 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 1,731,200 Value ($000) $205,667 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 1,350,000 Value ($000) $151,619 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 528,000 Value ($000) $49,991 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 160,000 Value ($000) $11,315 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 255,000 Value ($000) $18,947 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 338,000 Value ($000) $25,627 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 223,000 Value ($000) $17,853 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	210,287	$93,620	$460.83	$416.60 - $510.77
Q1 2025	159,900	$77,523	$466.00	$397.25 - $519.68
Q4 2024	151,000	$60,808	$463.53	$377.85 - $519.88
Q3 2024	151,000	$70,227	$480.37	$456.07 - $510.64
Q2 2024	151,000	$70,777	$434.05	$391.01 - $486.43
Q1 2024	122,700	$51,290	$422.74	$403.43 - $448.40
Q4 2023	175,200	$71,287	$369.42	$341.85 - $413.00
Q3 2023	165,400	$57,516	$349.73	$335.82 - $367.00
Q2 2023	165,400	$58,206	$336.94	$313.47 - $354.94
Q1 2023	177,600	$55,956	$299.93	$282.21 - $325.19
Q4 2022	271,500	$78,404	$304.77	$283.58 - $324.75
Q3 2022	373,200	$108,056	$287.72	$271.61 - $305.95
Q2 2022	387,200	$109,109	$267.66	$233.01 - $293.17
Q1 2022	400,200	$104,440	$237.33	$214.66 - $263.58
Q4 2021	658,100	$144,519	$194.45	$176.36 - $224.49
Q3 2021	877,400	$159,152	$195.24	$180.02 - $204.88
Q2 2021	1,065,400	$214,817	$209.17	$185.33 - $222.78
Q1 2021	1,135,900	$244,094	$219.65	$204.62 - $242.99
Q4 2020	834,100	$197,131	$229.44	$202.57 - $280.99
Q3 2020	666,100	$181,259	$275.88	$253.97 - $306.08
Q2 2020	666,100	$193,375	$271.12	$222.39 - $299.21
Q1 2020	737,400	$175,464	$229.39	$197.47 - $249.85
Q4 2019	783,100	$171,460	$202.38	$165.23 - $225.66
Q3 2019	846,400	$143,397	$176.91	$165.27 - $188.44
Q2 2019	973,300	$178,484	$174.82	$163.68 - $191.71
Q1 2019	955,300	$175,727	$184.70	$160.95 - $195.81
Q4 2018	1,133,200	$187,783	$173.27	$151.80 - $194.92
Q3 2018	1,600,500	$308,480	$178.07	$164.70 - $193.78
Q2 2018	1,792,600	$304,670	$155.01	$144.07 - $172.00
Q1 2018	1,854,600	$302,263	$163.34	$146.21 - $178.15
Q4 2017	1,741,300	$260,951	$148.07	$136.50 - $158.04
Q3 2017	2,074,302	$315,377	$150.51	$125.50 - $167.86
Q2 2017	2,026,502	$261,155	$120.38	$107.24 - $137.26
Q1 2017	2,169,200	$237,202	$88.04	$73.34 - $111.88
Q4 2016	2,159,400	$159,083	$81.37	$71.46 - $97.93
Q3 2016	1,612,000	$140,583	$94.50	$83.50 - $103.73
Q2 2016	2,189,300	$188,324	$86.41	$75.92 - $96.49
Q1 2016	1,869,400	$148,599	$90.45	$75.90 - $124.96
Q4 2015	673,000	$84,684	$120.72	$101.49 - $134.71
Q3 2015	115,000	$11,976	$128.47	$97.45 - $143.45
Q2 2015	115,000	$14,200	$125.98	$113.68 - $137.50
Q1 2015	135,000	$15,926	$119.81	$103.75 - $136.33
Q4 2014	1,731,200	$205,667	$112.63	$96.43 - $124.35
Q3 2014	1,350,000	$151,619	$95.21	$84.41 - $116.88
Q2 2014	528,000	$49,991	$70.12	$59.79 - $98.80
Q1 2014	160,000	$11,315	$79.20	$67.49 - $87.77
Q4 2013	255,000	$18,947	$69.64	$58.06 - $78.38
Q3 2013	338,000	$25,627	$79.58	$73.43 - $89.96
Q2 2013	223,000	$17,853	$73.64	$51.28 - $87.47