VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

RHUMBLINE ADVISERS's Holding History (CIK: 0001115418)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 431,262 Value ($000) $195,517 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 447,928 Value ($000) $175,426 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 454,372 Value ($000) $202,286 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 451,031 Value ($000) $218,669 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 442,361 Value ($000) $178,139 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 449,696 Value ($000) $209,145 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 457,905 Value ($000) $214,629 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 463,227 Value ($000) $193,633 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 458,488 Value ($000) $186,554 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 463,751 Value ($000) $161,265 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 463,326 Value ($000) $163,049 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 450,431 Value ($000) $142 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 426,737 Value ($000) $123 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 408,183 Value ($000) $118,185 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 395,995 Value ($000) $111,587 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 379,316 Value ($000) $98,990 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 392,266 Value ($000) $86,142 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 385,274 Value ($000) $69,885 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 400,756 Value ($000) $80,804 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 506,646 Value ($000) $108,873 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 522,252 Value ($000) $123,429 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 519,907 Value ($000) $141,477 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 532,564 Value ($000) $154,609 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 503,986 Value ($000) $119,923 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 501,645 Value ($000) $109,835 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 511,039 Value ($000) $86,580 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 486,549 Value ($000) $89,223 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 480,785 Value ($000) $88,440 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 454,416 Value ($000) $75,301 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 448,004 Value ($000) $86,348 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 453,117 Value ($000) $77,012 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 440,294 Value ($000) $71,759 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 447,935 Value ($000) $67,128 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 427,457 Value ($000) $64,991 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 421,320 Value ($000) $54,296 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 418,521 Value ($000) $45,765 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 415,762 Value ($000) $30,629 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 397,929 Value ($000) $34,703 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 377,088 Value ($000) $32,437 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 360,682 Value ($000) $28,671 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 346,892 Value ($000) $43,649 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 347,975 Value ($000) $36,238 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 343,714 Value ($000) $42,442 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 343,819 Value ($000) $40,560 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 340,196 Value ($000) $40,415 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 346,533 Value ($000) $38,919 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 361,689 Value ($000) $34,245 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 357,011 Value ($000) $25,248 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 350,766 Value ($000) $26,062 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 282,292 Value ($000) $21,403 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 386,514 Value ($000) $30,871 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	431,262	$195,517	$431.03	$392.50 - $464.44
Q3 2025	447,928	$175,426	$417.92	$362.50 - $484.56
Q2 2025	454,372	$202,286	$460.83	$416.60 - $510.77
Q1 2025	451,031	$218,669	$466.00	$397.25 - $519.68
Q4 2024	442,361	$178,139	$463.53	$377.85 - $519.88
Q3 2024	449,696	$209,145	$480.37	$456.07 - $510.64
Q2 2024	457,905	$214,629	$434.05	$391.01 - $486.43
Q1 2024	463,227	$193,633	$422.74	$403.43 - $448.40
Q4 2023	458,488	$186,554	$369.42	$341.85 - $413.00
Q3 2023	463,751	$161,265	$349.73	$335.82 - $367.00
Q2 2023	463,326	$163,049	$336.94	$313.47 - $354.94
Q1 2023	450,431	$142	$299.93	$282.21 - $325.19
Q4 2022	426,737	$123	$304.77	$283.58 - $324.75
Q3 2022	408,183	$118,185	$287.72	$271.61 - $305.95
Q2 2022	395,995	$111,587	$267.66	$233.01 - $293.17
Q1 2022	379,316	$98,990	$237.33	$214.66 - $263.58
Q4 2021	392,266	$86,142	$194.45	$176.36 - $224.49
Q3 2021	385,274	$69,885	$195.24	$180.02 - $204.88
Q2 2021	400,756	$80,804	$209.17	$185.33 - $222.78
Q1 2021	506,646	$108,873	$219.65	$204.62 - $242.99
Q4 2020	522,252	$123,429	$229.44	$202.57 - $280.99
Q3 2020	519,907	$141,477	$275.88	$253.97 - $306.08
Q2 2020	532,564	$154,609	$271.12	$222.39 - $299.21
Q1 2020	503,986	$119,923	$229.39	$197.47 - $249.85
Q4 2019	501,645	$109,835	$202.38	$165.23 - $225.66
Q3 2019	511,039	$86,580	$176.91	$165.27 - $188.44
Q2 2019	486,549	$89,223	$174.82	$163.68 - $191.71
Q1 2019	480,785	$88,440	$184.70	$160.95 - $195.81
Q4 2018	454,416	$75,301	$173.27	$151.80 - $194.92
Q3 2018	448,004	$86,348	$178.07	$164.70 - $193.78
Q2 2018	453,117	$77,012	$155.01	$144.07 - $172.00
Q1 2018	440,294	$71,759	$163.34	$146.21 - $178.15
Q4 2017	447,935	$67,128	$148.07	$136.50 - $158.04
Q3 2017	427,457	$64,991	$150.51	$125.50 - $167.86
Q2 2017	421,320	$54,296	$120.38	$107.24 - $137.26
Q1 2017	418,521	$45,765	$88.04	$73.34 - $111.88
Q4 2016	415,762	$30,629	$81.37	$71.46 - $97.93
Q3 2016	397,929	$34,703	$94.50	$83.50 - $103.73
Q2 2016	377,088	$32,437	$86.41	$75.92 - $96.49
Q1 2016	360,682	$28,671	$90.45	$75.90 - $124.96
Q4 2015	346,892	$43,649	$120.72	$101.49 - $134.71
Q3 2015	347,975	$36,238	$128.47	$97.45 - $143.45
Q2 2015	343,714	$42,442	$125.98	$113.68 - $137.50
Q1 2015	343,819	$40,560	$119.81	$103.75 - $136.33
Q4 2014	340,196	$40,415	$112.63	$96.43 - $124.35
Q3 2014	346,533	$38,919	$95.21	$84.41 - $116.88
Q2 2014	361,689	$34,245	$70.12	$59.79 - $98.80
Q1 2014	357,011	$25,248	$79.20	$67.49 - $87.77
Q4 2013	350,766	$26,062	$69.64	$58.06 - $78.38
Q3 2013	282,292	$21,403	$79.58	$73.43 - $89.96
Q2 2013	386,514	$30,871	$73.64	$51.28 - $87.47