VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Squarepoint Ops LLC's Holding History (CIK: 0001642575)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 389,020 Value ($000) $176,366 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 607,836 Value ($000) $238,053 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 175,687 Value ($000) $78,216 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 6,895 Value ($000) $3,343 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 9,092 Value ($000) $3,661 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 7,930 Value ($000) $3,688 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 25,103 Value ($000) $11,766 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 55,567 Value ($000) $23,228 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 21,410 Value ($000) $8,712 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 44,057 Value ($000) $15,320 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 9,870 Value ($000) $3,473 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 12,864 Value ($000) $4,053 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 43,497 Value ($000) $12,561 Avg Close $304.77 Range $283.58 - $324.75

Q4 2021

Shares 49,545 Value ($000) $10,880 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 153,756 Value ($000) $27,890 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 87,915 Value ($000) $17,726 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 134,241 Value ($000) $28,847 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 6,840 Value ($000) $1,617 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 65,288 Value ($000) $17,766 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 30,845 Value ($000) $8,955 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 13,600 Value ($000) $3,236 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 94,557 Value ($000) $20,703 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 56,225 Value ($000) $9,526 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 62,489 Value ($000) $11,459 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 188,608 Value ($000) $34,694 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 126,914 Value ($000) $21,031 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 71,392 Value ($000) $13,760 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 20,500 Value ($000) $3,484 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 113,229 Value ($000) $18,454 Avg Close $163.34 Range $146.21 - $178.15

Q3 2017

Shares 86,597 Value ($000) $13,166 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 131,277 Value ($000) $16,918 Avg Close $120.38 Range $107.24 - $137.26

Q4 2016

Shares 7,093 Value ($000) $523 Avg Close $81.37 Range $71.46 - $97.93

Q2 2016

Shares 3,302 Value ($000) $284 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 8,610 Value ($000) $684 Avg Close $90.45 Range $75.90 - $124.96

Q2 2015

Shares 1,988 Value ($000) $245 Avg Close $125.98 Range $113.68 - $137.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	389,020	$176,366	$431.03	$392.50 - $464.44
Q3 2025	607,836	$238,053	$417.92	$362.50 - $484.56
Q2 2025	175,687	$78,216	$460.83	$416.60 - $510.77
Q1 2025	6,895	$3,343	$466.00	$397.25 - $519.68
Q4 2024	9,092	$3,661	$463.53	$377.85 - $519.88
Q3 2024	7,930	$3,688	$480.37	$456.07 - $510.64
Q2 2024	25,103	$11,766	$434.05	$391.01 - $486.43
Q1 2024	55,567	$23,228	$422.74	$403.43 - $448.40
Q4 2023	21,410	$8,712	$369.42	$341.85 - $413.00
Q3 2023	44,057	$15,320	$349.73	$335.82 - $367.00
Q2 2023	9,870	$3,473	$336.94	$313.47 - $354.94
Q1 2023	12,864	$4,053	$299.93	$282.21 - $325.19
Q4 2022	43,497	$12,561	$304.77	$283.58 - $324.75
Q4 2021	49,545	$10,880	$194.45	$176.36 - $224.49
Q3 2021	153,756	$27,890	$195.24	$180.02 - $204.88
Q2 2021	87,915	$17,726	$209.17	$185.33 - $222.78
Q1 2021	134,241	$28,847	$219.65	$204.62 - $242.99
Q4 2020	6,840	$1,617	$229.44	$202.57 - $280.99
Q3 2020	65,288	$17,766	$275.88	$253.97 - $306.08
Q2 2020	30,845	$8,955	$271.12	$222.39 - $299.21
Q1 2020	13,600	$3,236	$229.39	$197.47 - $249.85
Q4 2019	94,557	$20,703	$202.38	$165.23 - $225.66
Q3 2019	56,225	$9,526	$176.91	$165.27 - $188.44
Q2 2019	62,489	$11,459	$174.82	$163.68 - $191.71
Q1 2019	188,608	$34,694	$184.70	$160.95 - $195.81
Q4 2018	126,914	$21,031	$173.27	$151.80 - $194.92
Q3 2018	71,392	$13,760	$178.07	$164.70 - $193.78
Q2 2018	20,500	$3,484	$155.01	$144.07 - $172.00
Q1 2018	113,229	$18,454	$163.34	$146.21 - $178.15
Q3 2017	86,597	$13,166	$150.51	$125.50 - $167.86
Q2 2017	131,277	$16,918	$120.38	$107.24 - $137.26
Q4 2016	7,093	$523	$81.37	$71.46 - $97.93
Q2 2016	3,302	$284	$86.41	$75.92 - $96.49
Q1 2016	8,610	$684	$90.45	$75.90 - $124.96
Q2 2015	1,988	$245	$125.98	$113.68 - $137.50